Frontostriatal system in planning complexity: a parametric functional magnetic resonance version of Tower of London task

O.A. van den Heuvel, H.J. Groenewegen, F. Barkhof, R.H.C. Lazeron, R. van Dyck, D.J. Veltman

Research output: Contribution to journalArticleAcademicpeer-review

179 Citations (Scopus)

Abstract

In the present study, we sought to investigate which brain structures are recruited in planning tasks of increasing complexity. For this purpose, a parametric self-paced pseudo-randomized event-related functional MRI version of the Tower of London task was designed. We tested 22 healthy subjects, enabling assessment of imaging results at a second (random effects) level of analysis. Compared with baseline, planning activity was correlated with increased blood oxygenation level-dependent (BOLD) signal in the dorsolateral prefrontal cortex, striatum, premotor cortex, supplementary motor area, and visuospatial system (precuneus and inferior parietal cortex). Task load was associated with increased activity in these same regions. In addition, increasing task complexity was correlated with activity in the left anterior prefrontal cortex, a region supposed to be specifically involved in third-order higher cognitive functioning.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalNeuroimage
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Feb 2003
Externally publishedYes

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Parietal Lobe
Motor Cortex
Prefrontal Cortex
Magnetic Resonance Spectroscopy
Healthy Volunteers
Magnetic Resonance Imaging
Brain

Keywords

  • Basal ganglia
  • Functional magnetic resonance imaging
  • Parametric
  • Planning
  • Prefrontal cortex
  • Tower of London

Cite this

van den Heuvel, O.A. ; Groenewegen, H.J. ; Barkhof, F. ; Lazeron, R.H.C. ; van Dyck, R. ; Veltman, D.J. / Frontostriatal system in planning complexity: a parametric functional magnetic resonance version of Tower of London task. In: Neuroimage. 2003 ; Vol. 18, No. 2. pp. 367-374.
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Frontostriatal system in planning complexity: a parametric functional magnetic resonance version of Tower of London task. / van den Heuvel, O.A.; Groenewegen, H.J.; Barkhof, F.; Lazeron, R.H.C.; van Dyck, R. ; Veltman, D.J.

In: Neuroimage, Vol. 18, No. 2, 01.02.2003, p. 367-374.

Research output: Contribution to journalArticleAcademicpeer-review

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