TY - JOUR
T1 - From molecular design to 3D printed life-like materials with unprecedented properties
AU - Wu, D.J.
AU - Bouten, C.V.C.
AU - Dankers, P.Y.W.
PY - 2017/6
Y1 - 2017/6
N2 - Stimuli-responsive synthetic materials have gained interest as biomaterials due to their ability to transform upon external stimuli. In order to mimic the cellular microenvironment synthetically, it is proposed that stimuli-responsiveness needs to be coupled with hierarchical supramolecular assembly of the materials applied. Additionally the mechanical properties of the microenvironment, i.e. the extracellular matrix, determine the nature of the tissue, which also needs to be mimicked in the material. Full control of mechanical properties, stimuli-responsiveness and hierarchical structure formation is proposed to be achieved by 3D printing of supramolecular systems into hierarchical structures that are able to react and adapt to stimuli, using metamaterial concepts. Therefore, in this review we discuss 3D printing of stimuli-responsive materials, and the design and development of metamaterials. Combination of these concepts with supramolecular chemistry is proposed to result in the design and synthesis of life-like biomaterials with unprecedented properties.
AB - Stimuli-responsive synthetic materials have gained interest as biomaterials due to their ability to transform upon external stimuli. In order to mimic the cellular microenvironment synthetically, it is proposed that stimuli-responsiveness needs to be coupled with hierarchical supramolecular assembly of the materials applied. Additionally the mechanical properties of the microenvironment, i.e. the extracellular matrix, determine the nature of the tissue, which also needs to be mimicked in the material. Full control of mechanical properties, stimuli-responsiveness and hierarchical structure formation is proposed to be achieved by 3D printing of supramolecular systems into hierarchical structures that are able to react and adapt to stimuli, using metamaterial concepts. Therefore, in this review we discuss 3D printing of stimuli-responsive materials, and the design and development of metamaterials. Combination of these concepts with supramolecular chemistry is proposed to result in the design and synthesis of life-like biomaterials with unprecedented properties.
KW - 3D printing
KW - Stimuli-responsive polymers
KW - Supramolecular chemistry
UR - http://www.mendeley.com/research/molecular-design-3d-printed-lifelike-materials-unprecedented-properties
UR - http://www.scopus.com/inward/record.url?scp=85054263990&partnerID=8YFLogxK
U2 - 10.1016/j.cobme.2017.06.001
DO - 10.1016/j.cobme.2017.06.001
M3 - Article
SN - 2468-4511
VL - 2
SP - 43
EP - 48
JO - Current Opinion in Biomedical Engineering
JF - Current Opinion in Biomedical Engineering
ER -