Forced peptide synthesis in nanoscale confinement under elastomeric stamps

T.P. Sullivan, M.L. Poll, van, P.Y.W. Dankers, W.T.S. Huck

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

Pressing a rubber stamp inked with carboxylic acids onto an amine-terminated surface leads to the formation of amide bonds at room temperature (see scheme). Oligopeptides were created on the surface in this way from a monolayer. This rapid and uncatalyzed formation of amide bonds is attributed to the nanoscale confinement of the molecules between the stamp and the preorganized monolayer substrate. PDMS=poly(dimethylsiloxane).
Original languageEnglish
Pages (from-to)4190-4193
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number32
DOIs
Publication statusPublished - 2004

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