Force-interval relationships of the heart measured with photoplethysmography during atrial fibrillation

Linda M. Eerikäinen, Alberto Bonomi, Lukas Dekker, Fons Schipper, Rik Vullings, Ronald M. Aarts

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)
1 Downloads (Pure)


Force-interval relationships (FIRs) of the heart represent the relationships between inter-beat intervals (IBIs) and strength of the ventricular contractions. These relationships are typically measured invasively and are altered from normal in heart failure (HF). An unobtrusive and continuous measurement of FIRs could be beneficial when HF and atrial fibrillation (AF) coexist in order to understand if AF causes progression of HF. We hypothesize that FIRs could be assessed during AF with IBIs and hemodynamic changes captured unobtrusively by photo-plethysmography (PPG) at the wrist. FIRs were assessed by using Spearman's rank correlation between the pulse onset change in the PPG waveform and either the preceding or pre-preceding IBIs (r pre\ and r pre-pre) in 5-minute segments. 32 patients (14 continuous AF, 18 no AF) were measured during the night with PPG and electrocardiography as a reference. The mean and standard deviation of r pre were -0.25± 0.08 and 0.05± 0.12(p < 0.0001), and of r pre-pre} 0.60± 0.09 and 0.16± 0.14 (p < 0.0001), during AF and sinus rhythm, respectively. Areas under the Receiver Operating Characteristics curve were 0.987 and 0.998, respectively. Thus, during AF the IBIs correlate with the beat-to-beat changes of blood volume measured with PPG, likely to indicate that FIRs can be measured unobtrusively with the PPG signal.

Original languageEnglish
Title of host publication45th Computing in Cardiology Conference, CinC 2018
Number of pages4
ISBN (Electronic)9781728109589
Publication statusPublished - 30 Dec 2018
Event45th Computing in Cardiology Conference (CinC 2018) - Maastricht, Netherlands
Duration: 23 Sep 201826 Sep 2018
Conference number: 45

Publication series

NameComputing in Cardiology
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X


Conference45th Computing in Cardiology Conference (CinC 2018)
Abbreviated titleCinC 2018


Dive into the research topics of 'Force-interval relationships of the heart measured with photoplethysmography during atrial fibrillation'. Together they form a unique fingerprint.

Cite this