Abstract
Force-interval relationships (FIRs) of the heart represent the relationships between inter-beat intervals (IBIs) and strength of the ventricular contractions. These relationships are typically measured invasively and are altered from normal in heart failure (HF). An unobtrusive and continuous measurement of FIRs could be beneficial when HF and atrial fibrillation (AF) coexist in order to understand if AF causes progression of HF. We hypothesize that FIRs could be assessed during AF with IBIs and hemodynamic changes captured unobtrusively by photo-plethysmography (PPG) at the wrist. FIRs were assessed by using Spearman's rank correlation between the pulse onset change in the PPG waveform and either the preceding or pre-preceding IBIs (r pre\ and r pre-pre) in 5-minute segments. 32 patients (14 continuous AF, 18 no AF) were measured during the night with PPG and electrocardiography as a reference. The mean and standard deviation of r pre were -0.25± 0.08 and 0.05± 0.12(p < 0.0001), and of r pre-pre} 0.60± 0.09 and 0.16± 0.14 (p < 0.0001), during AF and sinus rhythm, respectively. Areas under the Receiver Operating Characteristics curve were 0.987 and 0.998, respectively. Thus, during AF the IBIs correlate with the beat-to-beat changes of blood volume measured with PPG, likely to indicate that FIRs can be measured unobtrusively with the PPG signal.
Original language | English |
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Title of host publication | 45th Computing in Cardiology Conference, CinC 2018 |
Pages | 1-4 |
Number of pages | 4 |
ISBN (Electronic) | 9781728109589 |
DOIs | |
Publication status | Published - 30 Dec 2018 |
Event | 45th Computing in Cardiology Conference (CinC 2018) - Maastricht, Netherlands Duration: 23 Sep 2018 → 26 Sep 2018 Conference number: 45 |
Publication series
Name | Computing in Cardiology |
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Volume | 45 |
ISSN (Print) | 2325-8861 |
ISSN (Electronic) | 2325-887X |
Conference
Conference | 45th Computing in Cardiology Conference (CinC 2018) |
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Abbreviated title | CinC 2018 |
Country/Territory | Netherlands |
City | Maastricht |
Period | 23/09/18 → 26/09/18 |
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Cardiovascular Medicine
Lianne van de Laar (Content manager) & Jolanda Jansen (Content manager)
Impact: Research Topic/Theme (at group level)