Fiber scaffold patterning for mending hearts: 3D organization bringing the next step

Marleen Kristen (Corresponding author), Madison J. Ainsworth (Corresponding author), Nino Chirico, Casper F.T. van der Ven, Pieter A. Doevendans, Joost P.G. Sluijter, Jos Malda, Alain van Mil (Corresponding author), Miguel Castilho (Corresponding author)

Research output: Contribution to journalReview articlepeer-review

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Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.

Original languageEnglish
Article number1900775
Pages (from-to)e1900775
Number of pages21
JournalAdvanced Healthcare Materials
Issue number1
Early online date11 Oct 2019
Publication statusPublished - Jan 2020


M.K., M.J.A., N.C., C.F.T.v.d.V., A.v.M., and M.C. contributed equally to this work. Secondary shared authorship goes to N.C. and C.F.T.v.d.V. The authors gratefully thank the following agencies for their financial support: the strategic alliance University Medical Center Utrecht–Technical University Eindhoven, the H2020 European Research Council (ERC) (consolidator Grants 3D-JOINT, #647426 and EVICARE, #725229), the Gravitation Program “Materials Driven Regeneration” by the Netherlands Organization for Scientific Research (RegmedXB #024.003.013) and the Marie Skłodowska-Curie Actions (Grant agreement RESCUE #801540), and ReumaNederland (LLP-12). This work was also supported by the partners of Regenerative Medicine Crossing Borders ( and powered by Health∼Holland, Top Sector Life Sciences & Health.

FundersFunder number
Regenerative Medicine Crossing Borders
Universitair Medisch Centrum Utrecht
Horizon 2020 Framework Programme647426, 725229
H2020 European Research Council
Marie Skłodowska‐Curie801540, LLP-12
European Research Council
Nederlandse Organisatie voor Wetenschappelijk Onderzoek024.003.013


    • cardiac regeneration
    • cardiac tissue engineering
    • extracellular matrices
    • fiber manufacturing technologies
    • fiber scaffolds
    • instructive biomaterials


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