Abstract
Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.
Original language | English |
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Article number | 1900775 |
Pages (from-to) | e1900775 |
Number of pages | 21 |
Journal | Advanced Healthcare Materials |
Volume | 9 |
Issue number | 1 |
Early online date | 11 Oct 2019 |
DOIs | |
Publication status | Published - Jan 2020 |
Funding
M.K., M.J.A., N.C., C.F.T.v.d.V., A.v.M., and M.C. contributed equally to this work. Secondary shared authorship goes to N.C. and C.F.T.v.d.V. The authors gratefully thank the following agencies for their financial support: the strategic alliance University Medical Center Utrecht–Technical University Eindhoven, the H2020 European Research Council (ERC) (consolidator Grants 3D-JOINT, #647426 and EVICARE, #725229), the Gravitation Program “Materials Driven Regeneration” by the Netherlands Organization for Scientific Research (RegmedXB #024.003.013) and the Marie Skłodowska-Curie Actions (Grant agreement RESCUE #801540), and ReumaNederland (LLP-12). This work was also supported by the partners of Regenerative Medicine Crossing Borders (www.regmedxb.com) and powered by Health∼Holland, Top Sector Life Sciences & Health.
Funders | Funder number |
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UMC Utrecht | |
European Union's Horizon 2020 - Research and Innovation Framework Programme | 647426, 725229 |
Marie Skłodowska‐Curie | 801540, LLP-12 |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek | 024.003.013 |
Keywords
- cardiac regeneration
- cardiac tissue engineering
- extracellular matrices
- fiber manufacturing technologies
- fiber scaffolds
- instructive biomaterials