Fiber scaffold patterning for mending hearts: 3D organization bringing the next step

Marleen Kristen; Madison J. Ainsworth; Nino Chirico; Casper F.T. van der Ven; Pieter A. Doevendans; Joost P.G. Sluijter; Jos Malda; Alain van Mil; Miguel Castilho

doi:10.1002/adhm.201900775

Fiber scaffold patterning for mending hearts: 3D organization bringing the next step

Marleen Kristen (Corresponding author), Madison J. Ainsworth (Corresponding author), Nino Chirico, Casper F.T. van der Ven, Pieter A. Doevendans, Joost P.G. Sluijter, Jos Malda, Alain van Mil (Corresponding author), Miguel Castilho (Corresponding author)

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

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Abstract

Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.

Original language	English
Article number	1900775
Pages (from-to)	e1900775
Number of pages	21
Journal	Advanced Healthcare Materials
Volume	9
Issue number	1
Early online date	11 Oct 2019
DOIs	https://doi.org/10.1002/adhm.201900775
Publication status	Published - Jan 2020

Funding

M.K., M.J.A., N.C., C.F.T.v.d.V., A.v.M., and M.C. contributed equally to this work. Secondary shared authorship goes to N.C. and C.F.T.v.d.V. The authors gratefully thank the following agencies for their financial support: the strategic alliance University Medical Center Utrecht–Technical University Eindhoven, the H2020 European Research Council (ERC) (consolidator Grants 3D-JOINT, #647426 and EVICARE, #725229), the Gravitation Program “Materials Driven Regeneration” by the Netherlands Organization for Scientific Research (RegmedXB #024.003.013) and the Marie Skłodowska-Curie Actions (Grant agreement RESCUE #801540), and ReumaNederland (LLP-12). This work was also supported by the partners of Regenerative Medicine Crossing Borders (www.regmedxb.com) and powered by Health∼Holland, Top Sector Life Sciences & Health.

Funders	Funder number
UMC Utrecht
European Union's Horizon 2020 - Research and Innovation Framework Programme	647426, 725229
Marie Skłodowska‐Curie	801540, LLP-12
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	024.003.013

Keywords

cardiac regeneration
cardiac tissue engineering
extracellular matrices
fiber manufacturing technologies
fiber scaffolds
instructive biomaterials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adhm.201900775

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Cite this

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title = "Fiber scaffold patterning for mending hearts: 3D organization bringing the next step",

abstract = "Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.",

keywords = "cardiac regeneration, cardiac tissue engineering, extracellular matrices, fiber manufacturing technologies, fiber scaffolds, instructive biomaterials",

author = "Marleen Kristen and Ainsworth, {Madison J.} and Nino Chirico and {van der Ven}, {Casper F.T.} and Doevendans, {Pieter A.} and Sluijter, {Joost P.G.} and Jos Malda and {van Mil}, Alain and Miguel Castilho",

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AU - Chirico, Nino

AU - van der Ven, Casper F.T.

AU - Doevendans, Pieter A.

AU - Sluijter, Joost P.G.

AU - Malda, Jos

AU - van Mil, Alain

AU - Castilho, Miguel

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N2 - Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.

AB - Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.

KW - cardiac regeneration

KW - cardiac tissue engineering

KW - extracellular matrices

KW - fiber manufacturing technologies

KW - fiber scaffolds

KW - instructive biomaterials

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Fiber scaffold patterning for mending hearts: 3D organization bringing the next step

Abstract

Funding

Keywords

UN SDGs

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