Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors

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Abstract



Here we present the development of self-regulated “breathing” polymersome nanoreactors that show temporally programmable biocatalysis induced by a chemical fuel. pH-sensitive polymersomes loaded with horseradish peroxidase (HRP) and urease were developed. Addition of an acidic urea solution (“fuel”) endowed the polymersomes with a transient size increase and permeability enhancement, driving a temporal “ON” state of the HRP enzymatic catalysis; subsequent depletion of fuel led to shrinking of the polymersomes, resulting in the catalytic “OFF” state. Moreover, the nonequilibrium nanoreactors could be reinitiated several cycles as long as fuel was supplied. This feedback-induced temporal control of catalytic activity in polymersome nanoreactors provides a platform for functional nonequilibrium systems as well as for artificial organelles with precisely controlled adaptivity.
LanguageEnglish
Article number16
Pages5356–5359
JournalJournal of the American Chemical Society
Volume140
Issue number16
DOIs
StatePublished - 4 Apr 2018

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Nanoreactors
Horseradish Peroxidase
Respiration
Biocatalysis
Artificial Cells
Feedback
Urease
Catalysis
Urea
Permeability
Catalyst activity

Cite this

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title = "Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors",
abstract = "Here we present the development of self-regulated “breathing” polymersome nanoreactors that show temporally programmable biocatalysis induced by a chemical fuel. pH-sensitive polymersomes loaded with horseradish peroxidase (HRP) and urease were developed. Addition of an acidic urea solution (“fuel”) endowed the polymersomes with a transient size increase and permeability enhancement, driving a temporal “ON” state of the HRP enzymatic catalysis; subsequent depletion of fuel led to shrinking of the polymersomes, resulting in the catalytic “OFF” state. Moreover, the nonequilibrium nanoreactors could be reinitiated several cycles as long as fuel was supplied. This feedback-induced temporal control of catalytic activity in polymersome nanoreactors provides a platform for functional nonequilibrium systems as well as for artificial organelles with precisely controlled adaptivity.",
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Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors. / Che, H.; Cao, Shoupeng; van Hest, J.C.M.

In: Journal of the American Chemical Society, Vol. 140, No. 16, 16, 04.04.2018, p. 5356–5359.

Research output: Contribution to journalArticleAcademicpeer-review

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