FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder

Sanne K. Meles, David Vadasz, Remco J. Renken, Elisabeth Sittig-Wiegand, Geert Mayer, Candan Depboylu, Kathrin Reetz, Sebastiaan Overeem, Angelique Pijpers, Fransje E. Reesink, Teus van Laar, Lisette Heinen, Laura K. Teune, Helmut Höffken, Marcus Luster, Karl Kesper, Sofie M. Adriaanse, Jan Booij, Klaus L. Leenders, Wolfgang H. Oertel

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Abstract

Background Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD‐related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD‐related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder. Methods In this cross‐sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent 18F‐fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included 18F‐fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD‐related pattern expression z‐scores were computed from all PET scans. Results PD‐related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P = 0.048), but lower compared with PD (P = 0.001) and dementia with Lewy bodies (P < 0.0001). PD‐related pattern expression was higher in idiopathic REM sleep behavior disorder subjects with hyposmia and in subjects with an abnormal dopamine transporter scan (P < 0.05, uncorrected). Conclusion PD‐related pattern expression, dopamine transporter binding, and olfaction may provide complementary information for predicting phenoconversion. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Original languageEnglish
Pages (from-to)1482-1486
Number of pages5
JournalMovement Disorders
Volume32
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • F-FDG-PET
  • dopamine transporter I-FP-CIT SPECT
  • idiopathic REM sleep behavior disorder
  • olfaction
  • Parkinson's disease-related pattern
  • Parkinson Disease/diagnostic imaging
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Tomography, Emission-Computed, Single-Photon
  • Male
  • Positron-Emission Tomography
  • Psychiatric Status Rating Scales
  • Analysis of Variance
  • Dopamine Plasma Membrane Transport Proteins/metabolism
  • Olfaction Disorders/diagnostic imaging
  • Female
  • Fluorodeoxyglucose F18
  • Aged
  • REM Sleep Behavior Disorder/complications
  • Lewy Body Disease/diagnostic imaging

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