Fast scale-up using microreactors: Pyrrole synthesis from micro to production scale

Pieter Nieuwland; Ruth Segers; K. Koch; J.C.M. Hest, van; F.P.J.T. Rutjes

doi:10.1021/op100338z

Fast scale-up using microreactors: Pyrrole synthesis from micro to production scale

Pieter Nieuwland
, Ruth Segers
, K. Koch
, J.C.M. Hest, van
, F.P.J.T. Rutjes

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

Abstract

A flow chemistry method for the synthesis of pyrroles was developed. The method was optimized in 0.13 to 7 μL microreactors in continuous flow, reaching yields of nearly 100%. Subsequently, the method was scaled up in continuous flow using a 9.6-mL internal volume, glass, microstructured flow reactor, leading to production of a pyrrole derivative at a rate of 55.8 g per hour.

Original language	English
Pages (from-to)	783-787
Number of pages	5
Journal	Organic Process Research & Development
Volume	15
Issue number	4
DOIs	https://doi.org/10.1021/op100338z
Publication status	Published - 15 Jul 2011
Externally published	Yes

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10.1021/op100338z

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abstract = "A flow chemistry method for the synthesis of pyrroles was developed. The method was optimized in 0.13 to 7 μL microreactors in continuous flow, reaching yields of nearly 100\%. Subsequently, the method was scaled up in continuous flow using a 9.6-mL internal volume, glass, microstructured flow reactor, leading to production of a pyrrole derivative at a rate of 55.8 g per hour.",

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AU - Nieuwland, Pieter

AU - Segers, Ruth

AU - Koch, K.

AU - Hest, van, J.C.M.

AU - Rutjes, F.P.J.T.

PY - 2011/7/15

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AB - A flow chemistry method for the synthesis of pyrroles was developed. The method was optimized in 0.13 to 7 μL microreactors in continuous flow, reaching yields of nearly 100%. Subsequently, the method was scaled up in continuous flow using a 9.6-mL internal volume, glass, microstructured flow reactor, leading to production of a pyrrole derivative at a rate of 55.8 g per hour.

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JO - Organic Process Research & Development

JF - Organic Process Research & Development

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Fast scale-up using microreactors: Pyrrole synthesis from micro to production scale

Abstract

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