Fast scale up using microreactors: From microscale to production

P.J. Nieuwland; K. Koch; R. Becker; J.C.M. Hest, van; F.P.J.T. Rutjes

Fast scale up using microreactors: From microscale to production

P.J. Nieuwland
, K. Koch
, R. Becker
, J.C.M. Hest, van
, F.P.J.T. Rutjes

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

In this study, the excellent scalability of flow chemistry was shown. Selective formation of mono-a-bromoketones was chosen as a model reaction. In a full multivariate optimization experiment, 60 different settings for reaction parameters such as temperature and reaction time were screened, requiring only small amounts of chemicals. A mathematical model of the data was obtained and an optimum set of reaction parameters was selected. These settings were applied on a larger scale continuous flow system and led to a production of the target compound phenacyl bromide at a 1.1 g/hr rate.

Original language	English
Title of host publication	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages	995-997
Number of pages	3
Volume	2
Publication status	Published - 2010
Externally published	Yes
Event	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010 - Groningen, Netherlands Duration: 3 Oct 2010 → 7 Oct 2010 Conference number: 14 http://www.microtasconferences.org/microtas2010/

Conference

Conference	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010
Abbreviated title	MicroTAS 2010
Country/Territory	Netherlands
City	Groningen
Period	3/10/10 → 7/10/10
Internet address	http://www.microtasconferences.org/microtas2010/

Keywords

Bromination
Flow Chemistry
Microreactors
Scale-up

Cite this

@inproceedings{89201501f42b499ab97bbdcfb3b81616,

title = "Fast scale up using microreactors: From microscale to production",

abstract = "In this study, the excellent scalability of flow chemistry was shown. Selective formation of mono-a-bromoketones was chosen as a model reaction. In a full multivariate optimization experiment, 60 different settings for reaction parameters such as temperature and reaction time were screened, requiring only small amounts of chemicals. A mathematical model of the data was obtained and an optimum set of reaction parameters was selected. These settings were applied on a larger scale continuous flow system and led to a production of the target compound phenacyl bromide at a 1.1 g/hr rate.",

keywords = "Bromination, Flow Chemistry, Microreactors, Scale-up",

author = "P.J. Nieuwland and K. Koch and R. Becker and \{Hest, van\}, J.C.M. and F.P.J.T. Rutjes",

year = "2010",

language = "English",

isbn = "9781618390622",

volume = "2",

pages = "995--997",

booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",

note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",

url = "http://www.microtasconferences.org/microtas2010/",

}

Nieuwland, PJ, Koch, K, Becker, R, Hest, van, JCM & Rutjes, FPJT 2010, Fast scale up using microreactors: From microscale to production. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. vol. 2, pp. 995-997, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010, Groningen, Netherlands, 3/10/10.

TY - GEN

T1 - Fast scale up using microreactors

T2 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010

AU - Nieuwland, P.J.

AU - Koch, K.

AU - Becker, R.

AU - Hest, van, J.C.M.

AU - Rutjes, F.P.J.T.

N1 - Conference code: 14

PY - 2010

Y1 - 2010

N2 - In this study, the excellent scalability of flow chemistry was shown. Selective formation of mono-a-bromoketones was chosen as a model reaction. In a full multivariate optimization experiment, 60 different settings for reaction parameters such as temperature and reaction time were screened, requiring only small amounts of chemicals. A mathematical model of the data was obtained and an optimum set of reaction parameters was selected. These settings were applied on a larger scale continuous flow system and led to a production of the target compound phenacyl bromide at a 1.1 g/hr rate.

AB - In this study, the excellent scalability of flow chemistry was shown. Selective formation of mono-a-bromoketones was chosen as a model reaction. In a full multivariate optimization experiment, 60 different settings for reaction parameters such as temperature and reaction time were screened, requiring only small amounts of chemicals. A mathematical model of the data was obtained and an optimum set of reaction parameters was selected. These settings were applied on a larger scale continuous flow system and led to a production of the target compound phenacyl bromide at a 1.1 g/hr rate.

KW - Bromination

KW - Flow Chemistry

KW - Microreactors

KW - Scale-up

UR - https://www.scopus.com/pages/publications/84884358796

M3 - Conference contribution

AN - SCOPUS:84884358796

SN - 9781618390622

VL - 2

SP - 995

EP - 997

BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

Y2 - 3 October 2010 through 7 October 2010

ER -

Fast scale up using microreactors: From microscale to production

Abstract

Conference

Keywords

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