Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma

Giovanni Borasi, Alan Nahum, Maarten Paulides, Gibin Powathil, Giorgio Russo, Laura Fariselli, Debora Lamia, Roberta Cirincione, Giusi Irma Forte, Cristian Borrazzo, Barbara Caccia, Elisabetta di Castro, Silvia Pozzi, Maria Carla Gilardi

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
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BACKGROUND: A new transcranial focused ultrasound device has been developed that can induce hyperthermia in a large tissue volume. The purpose of this work is to investigate theoretically how glioblastoma multiforme (GBM) can be effectively treated by combining the fast hyperthermia generated by this focused ultrasound device with external beam radiotherapy.

METHODS/DESIGN: To investigate the effect of tumor growth, we have developed a mathematical description of GBM proliferation and diffusion in the context of reaction-diffusion theory. In addition, we have formulated equations describing the impact of radiotherapy and heat on GBM in the reaction-diffusion equation, including tumor regrowth by stem cells. This formulation has been used to predict the effectiveness of the combination treatment for a realistic focused ultrasound heating scenario. Our results show that patient survival could be significantly improved by this combined treatment modality.

DISCUSSION: High priority should be given to experiments to validate the therapeutic benefit predicted by our model.

Original languageEnglish
Article number32
Number of pages10
JournalJournal of Therapeutic Ultrasound
Publication statusPublished - 2016
Externally publishedYes


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