Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma

Giovanni Borasi; Alan Nahum; Maarten Paulides; Gibin Powathil; Giorgio Russo; Laura Fariselli; Debora Lamia; Roberta Cirincione; Giusi Irma Forte; Cristian Borrazzo; Barbara Caccia; Elisabetta di Castro; Silvia Pozzi; Maria Carla Gilardi

doi:10.1186/s40349-016-0078-3

Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma

Giovanni Borasi, Alan Nahum, Maarten Paulides, Gibin Powathil, Giorgio Russo, Laura Fariselli, Debora Lamia, Roberta Cirincione, Giusi Irma Forte, Cristian Borrazzo, Barbara Caccia, Elisabetta di Castro, Silvia Pozzi, Maria Carla Gilardi

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: A new transcranial focused ultrasound device has been developed that can induce hyperthermia in a large tissue volume. The purpose of this work is to investigate theoretically how glioblastoma multiforme (GBM) can be effectively treated by combining the fast hyperthermia generated by this focused ultrasound device with external beam radiotherapy.

METHODS/DESIGN: To investigate the effect of tumor growth, we have developed a mathematical description of GBM proliferation and diffusion in the context of reaction-diffusion theory. In addition, we have formulated equations describing the impact of radiotherapy and heat on GBM in the reaction-diffusion equation, including tumor regrowth by stem cells. This formulation has been used to predict the effectiveness of the combination treatment for a realistic focused ultrasound heating scenario. Our results show that patient survival could be significantly improved by this combined treatment modality.

DISCUSSION: High priority should be given to experiments to validate the therapeutic benefit predicted by our model.

Original language	English
Article number	32
Number of pages	10
Journal	Journal of Therapeutic Ultrasound
Volume	4
DOIs	https://doi.org/10.1186/s40349-016-0078-3
Publication status	Published - 2016
Externally published	Yes

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Borasi, G., Nahum, A., Paulides, M., Powathil, G., Russo, G., Fariselli, L., Lamia, D., Cirincione, R., Forte, G. I., Borrazzo, C., Caccia, B., di Castro, E., Pozzi, S., & Gilardi, M. C. (2016). Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma. Journal of Therapeutic Ultrasound, 4, Article 32. https://doi.org/10.1186/s40349-016-0078-3

@article{c558bf0a73dd4486866dbf4b4d60d4cf,

title = "Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma",

abstract = "BACKGROUND: A new transcranial focused ultrasound device has been developed that can induce hyperthermia in a large tissue volume. The purpose of this work is to investigate theoretically how glioblastoma multiforme (GBM) can be effectively treated by combining the fast hyperthermia generated by this focused ultrasound device with external beam radiotherapy.METHODS/DESIGN: To investigate the effect of tumor growth, we have developed a mathematical description of GBM proliferation and diffusion in the context of reaction-diffusion theory. In addition, we have formulated equations describing the impact of radiotherapy and heat on GBM in the reaction-diffusion equation, including tumor regrowth by stem cells. This formulation has been used to predict the effectiveness of the combination treatment for a realistic focused ultrasound heating scenario. Our results show that patient survival could be significantly improved by this combined treatment modality.DISCUSSION: High priority should be given to experiments to validate the therapeutic benefit predicted by our model.",

author = "Giovanni Borasi and Alan Nahum and Maarten Paulides and Gibin Powathil and Giorgio Russo and Laura Fariselli and Debora Lamia and Roberta Cirincione and Forte, {Giusi Irma} and Cristian Borrazzo and Barbara Caccia and {di Castro}, Elisabetta and Silvia Pozzi and Gilardi, {Maria Carla}",

year = "2016",

doi = "10.1186/s40349-016-0078-3",

language = "English",

volume = "4",

journal = "Journal of Therapeutic Ultrasound",

issn = "2050-5736",

publisher = "BioMed Central",

}

Borasi, G, Nahum, A, Paulides, M, Powathil, G, Russo, G, Fariselli, L, Lamia, D, Cirincione, R, Forte, GI, Borrazzo, C, Caccia, B, di Castro, E, Pozzi, S & Gilardi, MC 2016, 'Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma', Journal of Therapeutic Ultrasound, vol. 4, 32. https://doi.org/10.1186/s40349-016-0078-3

TY - JOUR

T1 - Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma

AU - Borasi, Giovanni

AU - Nahum, Alan

AU - Paulides, Maarten

AU - Powathil, Gibin

AU - Russo, Giorgio

AU - Fariselli, Laura

AU - Lamia, Debora

AU - Cirincione, Roberta

AU - Forte, Giusi Irma

AU - Borrazzo, Cristian

AU - Caccia, Barbara

AU - di Castro, Elisabetta

AU - Pozzi, Silvia

AU - Gilardi, Maria Carla

PY - 2016

Y1 - 2016

N2 - BACKGROUND: A new transcranial focused ultrasound device has been developed that can induce hyperthermia in a large tissue volume. The purpose of this work is to investigate theoretically how glioblastoma multiforme (GBM) can be effectively treated by combining the fast hyperthermia generated by this focused ultrasound device with external beam radiotherapy.METHODS/DESIGN: To investigate the effect of tumor growth, we have developed a mathematical description of GBM proliferation and diffusion in the context of reaction-diffusion theory. In addition, we have formulated equations describing the impact of radiotherapy and heat on GBM in the reaction-diffusion equation, including tumor regrowth by stem cells. This formulation has been used to predict the effectiveness of the combination treatment for a realistic focused ultrasound heating scenario. Our results show that patient survival could be significantly improved by this combined treatment modality.DISCUSSION: High priority should be given to experiments to validate the therapeutic benefit predicted by our model.

AB - BACKGROUND: A new transcranial focused ultrasound device has been developed that can induce hyperthermia in a large tissue volume. The purpose of this work is to investigate theoretically how glioblastoma multiforme (GBM) can be effectively treated by combining the fast hyperthermia generated by this focused ultrasound device with external beam radiotherapy.METHODS/DESIGN: To investigate the effect of tumor growth, we have developed a mathematical description of GBM proliferation and diffusion in the context of reaction-diffusion theory. In addition, we have formulated equations describing the impact of radiotherapy and heat on GBM in the reaction-diffusion equation, including tumor regrowth by stem cells. This formulation has been used to predict the effectiveness of the combination treatment for a realistic focused ultrasound heating scenario. Our results show that patient survival could be significantly improved by this combined treatment modality.DISCUSSION: High priority should be given to experiments to validate the therapeutic benefit predicted by our model.

U2 - 10.1186/s40349-016-0078-3

DO - 10.1186/s40349-016-0078-3

M3 - Article

C2 - 27980785

SN - 2050-5736

VL - 4

JO - Journal of Therapeutic Ultrasound

JF - Journal of Therapeutic Ultrasound

M1 - 32

ER -

Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma

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