Factors determining flow rate in chromatographic columns

C.A.M.G. Cramers; J.A. Rijks; C.P.M. Schutjes

doi:10.1007/BF02262882

Factors determining flow rate in chromatographic columns

C.A.M.G. Cramers, J.A. Rijks, C.P.M. Schutjes

Chemical Engineering and Chemistry

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Abstract

It is shown that the flow in chromatography is nearly always laminar in nature. Starting from the Darcy equation, expressions are given for the flow rate in both gas and liquid chromatography columns. The concepts of specific permeability, chromatographic permeability and column resistance factor are discussed for packed as well as open tubular columns. The experimental determination of all these factoers is demonstrated. The influence of the shape and pore volume of porous and non-porous supports on the column resistance factor and the chromatographic permeability is discussed.

Original language	English
Pages (from-to)	439-444
Number of pages	6
Journal	Chromatographia
Volume	14
Issue number	7
DOIs	https://doi.org/10.1007/BF02262882
Publication status	Published - 1981

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title = "Factors determining flow rate in chromatographic columns",

abstract = "It is shown that the flow in chromatography is nearly always laminar in nature. Starting from the Darcy equation, expressions are given for the flow rate in both gas and liquid chromatography columns. The concepts of specific permeability, chromatographic permeability and column resistance factor are discussed for packed as well as open tubular columns. The experimental determination of all these factoers is demonstrated. The influence of the shape and pore volume of porous and non-porous supports on the column resistance factor and the chromatographic permeability is discussed.",

author = "C.A.M.G. Cramers and J.A. Rijks and C.P.M. Schutjes",

year = "1981",

doi = "10.1007/BF02262882",

language = "English",

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journal = "Chromatographia",

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number = "7",

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T1 - Factors determining flow rate in chromatographic columns

AU - Cramers, C.A.M.G.

AU - Rijks, J.A.

AU - Schutjes, C.P.M.

PY - 1981

Y1 - 1981

N2 - It is shown that the flow in chromatography is nearly always laminar in nature. Starting from the Darcy equation, expressions are given for the flow rate in both gas and liquid chromatography columns. The concepts of specific permeability, chromatographic permeability and column resistance factor are discussed for packed as well as open tubular columns. The experimental determination of all these factoers is demonstrated. The influence of the shape and pore volume of porous and non-porous supports on the column resistance factor and the chromatographic permeability is discussed.

AB - It is shown that the flow in chromatography is nearly always laminar in nature. Starting from the Darcy equation, expressions are given for the flow rate in both gas and liquid chromatography columns. The concepts of specific permeability, chromatographic permeability and column resistance factor are discussed for packed as well as open tubular columns. The experimental determination of all these factoers is demonstrated. The influence of the shape and pore volume of porous and non-porous supports on the column resistance factor and the chromatographic permeability is discussed.

U2 - 10.1007/BF02262882

DO - 10.1007/BF02262882

M3 - Article

VL - 14

SP - 439

EP - 444

JO - Chromatographia

JF - Chromatographia

SN - 0009-5893

IS - 7

ER -