Factors determining flow rate in chromatographic columns

C.A.M.G. Cramers, J.A. Rijks, C.P.M. Schutjes

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Abstract

It is shown that the flow in chromatography is nearly always laminar in nature. Starting from the Darcy equation, expressions are given for the flow rate in both gas and liquid chromatography columns. The concepts of specific permeability, chromatographic permeability and column resistance factor are discussed for packed as well as open tubular columns. The experimental determination of all these factoers is demonstrated. The influence of the shape and pore volume of porous and non-porous supports on the column resistance factor and the chromatographic permeability is discussed.
Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalChromatographia
Volume14
Issue number7
DOIs
Publication statusPublished - 1981

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