Facilitating control of fed-batch fermentation processes by monitoring the growth rates of Saccharomyces cerevisiae

M.L.B. Keulers, L.J.J.M. Ariaans, R. Soeterboek, M. Giuseppin

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

In this paper we present a growth rate controller for a fed-batch bioprocess. An observer estimates the growth rate. The observer is based on knowledge about the stoichiometric relations of the process. Furthermore, the observer needs online measurements of the oxygen uptake rate and the carbon-dioxide production rate. The control structure is a simple one, and the fed-batch fermentation process is inherently nonlinear. A growth rate dependent precompensation is introduced to linearise the process. The remaining control actions can then be tackled using a normal PI-controller. Simulation studies show good performance for oxidative growth on glucose. Deterioration of the control is expected if the growth rate becomes bigger than the critical growth rate. Furthermore, some non-modelled dynamical effects occur during set-point changes. To some extend these effects can be modelled and the model can be incorporated in the controller. The overall performance of the controller increases. Yet this improvement is at the cost of a more complex structure. A trade off has to be found between control performance and controller complexity
Original languageEnglish
Title of host publication3rd IEEE Conference on Control Applications, Glasgow, UK, 24 August 1994
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Pages1935-1940
ISBN (Print)0-7803-1872-2
DOIs
Publication statusPublished - 1994
Event1994 IEEE Conference on Control Applications (CCA 1994) - Strathclyde University, Glasgow, United Kingdom
Duration: 24 Aug 199426 Aug 1994
Conference number: 3

Conference

Conference1994 IEEE Conference on Control Applications (CCA 1994)
Abbreviated titleCCA 1994
Country/TerritoryUnited Kingdom
CityGlasgow
Period24/08/9426/08/94
OtherThird IEEE Conference on Control Applications, Control Applications (Glasgow, UK), August 24th-26th, 1994

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