Fabrication of Polymer/Graphene Biocomposites for Tissue Engineering

João Meneses, Tom van de Kemp, Raquel Costa-Almeida, Rúben Pereira, Fernão D. Magalhães, Miguel Castilho, Artur M. Pinto (Corresponding author)

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
39 Downloads (Pure)

Abstract

Graphene-based materials (GBM) are considered one of the 21st century’s most promising materials, as they are incredibly light, strong, thin and have remarkable electrical and thermal properties. As a result, over the past decade, their combination with a diverse range of synthetic polymers has been explored in tissue engineering (TE) and regenerative medicine (RM). In addition, a wide range of methods for fabricating polymer/GBM scaffolds have been reported. This review provides an overview of the most recent advances in polymer/GBM composite development and fabrication, focusing on methods such as electrospinning and additive manufacturing (AM). As a future outlook, this work stresses the need for more in vivo studies to validate polymer/GBM composite scaffolds for TE applications, and gives insight on their fabrication by state-of-the-art processing technologies.

Original languageEnglish
Article number1038
Number of pages25
JournalPolymers
Volume14
Issue number5
DOIs
Publication statusPublished - 4 Mar 2022

Bibliographical note

Funding Information:
This work was financially supported by LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE), funded by national funds through FCT/MCTES (PIDDAC), base UIDB/04293/2020 Funding of the Institute for Research and Innovation in Health-i3S. This work was financed by FEDER funds through the COMPETE 2020?Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by national funds (PIDDAC) through FCT/MCTES in the framework of the project POCI-01-0145-FEDER-031143, NovaDerma?New platforms for dermatological phototherapy (PTDC/BTM-MAT/31143/2017). Project 2SMART?en-gineered Smart materials for Smart citizens, with reference NORTE-01-0145-FEDER-000054, supported by the Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Project SbDToolBox ? Nanotechnology-based tools and tests for Safe-by-Design nanomaterials, with reference NORTE-01-0145-FEDER-000047, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Artur Pinto thanks the Portuguese Foundation for Science and Technology (FCT) for the financial support of his work contract through the Scientific Employ-ment Stimulus?Individual Call?[CEECIND/03908/2017]. MC gratefully thanks the following agencies for their financial support: the European Union?s Horizon 2020 research and innovation programme under the grant agreement No. 874827 (BRAV?), the Gravitation Program ?Materials Driven Regeneration? (024.003.013), the Reprint project (OCENW.XS5.161) by the Netherlands Organization for Scientific Research, and the Marie Sk?odowska?Curie Actions (RESCUE #801540). This work was also supported by the partners of Regenerative Medicine Crossing Borders and pow-ered by Health~Holland, TopSector Life Sciences & Health.

Keywords

  • Additive manufacturing
  • Electrospinning
  • Graphene-based materials
  • Synthetic poly-mers
  • Tissue engineering

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