TY - JOUR
T1 - Externally triggered glass transition switch for localized on-demand drug delivery
AU - Keurentjes, J.T.F.
AU - Kemmere, M.F.
AU - Bruinewoud, H.
AU - Vertommen, M.A.M.E.
AU - Rovers, S.A.
AU - Hoogenboom, R.
AU - Stemkens, L.F.S.
AU - Peters, F.L.A.M.A.
AU - Tielen, N.J.C.
AU - Asseldonk, van, D.T.A.
AU - Gabriel, A.F.
AU - Joosten, E.A.
AU - Marcus, M.A.E.
PY - 2009
Y1 - 2009
N2 - want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).
AB - want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).
U2 - 10.1002/anie.200904172
DO - 10.1002/anie.200904172
M3 - Article
C2 - 19943293
SN - 0570-0833
VL - 48
SP - 9867
EP - 9870
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 52
ER -