Externally triggered glass transition switch for localized on-demand drug delivery

J.T.F. Keurentjes, M.F. Kemmere, H. Bruinewoud, M.A.M.E. Vertommen, S.A. Rovers, R. Hoogenboom, L.F.S. Stemkens, F.L.A.M.A. Peters, N.J.C. Tielen, D.T.A. Asseldonk, van, A.F. Gabriel, E.A. Joosten, M.A.E. Marcus

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Abstract

want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).
Original languageEnglish
Pages (from-to)9867-9870
JournalAngewandte Chemie - International Edition
Volume48
Issue number52
DOIs
Publication statusPublished - 2009

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