Abstract
The exposure of biological cells to an incident electric field (EF) affects cellular behaviour. However, the interaction mechanisms are still a matter of discussion. Although most of the evidence comes from experimental trials, numerical simulations are helpful to obviate the lack of reproducible experimental results and to resolve contradictory conclusions. In this work we present a numerical framework for computing the intracellular EF in arbitrary-shaped biological cells with nucleus. As an example, up to four inhomogeneous cells exposed to an incident EF of 1 V/m at 2.45 GHz are studied. The solution is obtained by implementing the electric flux volume integral equation (VIE) and the Method of Moments (MoM) with SchaubertWilton-Glisson (SWG) basis functions. Qualitative results show that the intracellular EF is related to the neighboring cells in terms of number and position. Quantitative analysis shows intracellular variations in the order of 20-30 mV/mm, which might be enough to trigger biological responses in cells. Therefore, this approach may be suitable to further investigate the cell-cell EF interactions, especially in non-canonical shaped cells with non-concentric nucleus.
Original language | English |
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Title of host publication | Proceedings of the 8th European Conference on Antennas and Propagation (EUCAP 2014), 6-11 April 2014, The Hague, The Netherlands |
Place of Publication | Piscataway |
Publisher | Institute of Electrical and Electronics Engineers |
Pages | 3189-3193 |
Number of pages | 5 |
ISBN (Print) | 978-88-907018-4-9 |
DOIs | |
Publication status | Published - 2014 |
Event | 8th European Conference on Antennas and Propagation (EuCAP 2014) - The Hague, Netherlands Duration: 6 Apr 2014 → 11 Apr 2014 Conference number: 8 http://www.eucap2014.org/ |
Conference
Conference | 8th European Conference on Antennas and Propagation (EuCAP 2014) |
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Abbreviated title | EuCAP 2014 |
Country/Territory | Netherlands |
City | The Hague |
Period | 6/04/14 → 11/04/14 |
Internet address |