Excessive volume of hydrogel injectates may compromise the efficacy for the treatment of acute myocardial infarction

P. Wise, N.H. Davies, M.S. Sirry, J. Kortsmit, L. Dubuis, C.-K. Chai, F.P.T. Baaijens, T. Franz

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
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Abstract

Biomaterial injectates are promising as a therapy for myocardial infarction to inhibit the adverse ventricular remodeling. The current study explored interrelated effects of injectate volume and infarct size on treatment efficacy. A finite element model of a rat heart was utilized to represent ischemic infarcts of 10%, 20%, and 38% of left ventricular wall volume and polyethylene glycol hydrogel injectates of 25%, 50%, and 75% of the infarct volume. Ejection fraction was 49.7% in the healthy left ventricle and 44.9%, 46.4%, 47.4%, and 47.3% in the untreated 10% infarct and treated with 25%, 50%, and 75% injectate, respectively. Maximum end-systolic infarct fiber stress was 41.6, 53.4, 44.7, 44.0, and 45.3 kPa in the healthy heart, the untreated 10% infarct, and when treated with the three injectate volumes, respectively. Treating the 10% and 38% infarcts with the 25% injectate volume reduced the maximum end-systolic fiber stress by 16.3% and 34.7% and the associated strain by 30.2% and 9.8%, respectively. The results indicate the existence of a threshold for injectate volume above which efficacy does not further increase but may decrease. The efficacy of an injectate in reducing infarct stress and strain changes with infarct size.

Original languageEnglish
Article numbere02772
Pages (from-to)1-14
JournalInternational Journal for Numerical Methods in Biomedical Engineering
Volume32
Issue number12
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • biomaterial
  • cardiac function
  • finite element method
  • indentation tests
  • polyethylene glycol
  • ventricular remodeling

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