Ex vivo photoacoustic imaging of atherosclerotic carotid plaques

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Abstract

Vulnerability assessment of carotid plaques is vital to prevent atherosclerosis-related mortality and disability. Photoacoustic imaging (PAI) in combination with plane-wave ultrasound (PUS) may have the ability to reveal the composition and the anatomical structure of the plaque, which infers its mechanical properties and vulnerability. In this study, we used PAI and PUS imaging to scan endarterectomy samples ex vivo, targeting intraplaque hemorrhage, and compared the results with those obtained in healthy (porcine) carotids and histology. A fully integrated hand-held photoacoustic probe was used, consisting of a pulsed diode laser (tp = 130 ns, Ep = 1 mJ, λ = 808 nm) and a linear array transducer (fc = 7.5 MHz). Three porcine carotid arteries and six carotid plaque samples were obtained from a local slaughterhouse and hospital respectively, and were mounted to the imaging setup. Data of endarterectomy samples revealed that PAI of carotid plaques at 808 nm wavelength is capable of detecting blood clots, which can be extensions of vasculature in the plaque, intra-plaque hemorrhage, or the result of trauma inflicted on the medial vascularization. Due to calcification and the limited optical penetration, imaging depth was mostly limited to the proximal wall of the samples. The porcine carotids revealed no hemorrhaging, which was corroborated by the lack of PAI contrast.

Original languageEnglish
Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
PublisherInstitute of Electrical and Electronics Engineers
Number of pages4
ISBN (Print)9781479981823
DOIs
Publication statusPublished - 13 Nov 2015
Event2015 IEEE International Ultrasonics Symposium (IUS 2015) - Taipei International Convention Center, Taipei, Taiwan
Duration: 21 Oct 201524 Oct 2015
http://ewh.ieee.org/conf/ius/ius_2015/

Conference

Conference2015 IEEE International Ultrasonics Symposium (IUS 2015)
Abbreviated title2015 IUS
CountryTaiwan
CityTaipei
Period21/10/1524/10/15
Internet address

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