Evaluation of the viability of hl60 cells in contact with commonly used microchip materials

F. Wolbers, P.M. Braak, ter, S. Gac, Le, R. Luttge, H. Andersson, I. Vermes, A. Berg, van den

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


This paper presents beneficial data when deciding to perform cell experiments in lab-ona- chip devices. The choice of material can influence the viability of mammalian cells. PDMS, precoated with serum or not, suits well for HL60 cells, demonstrating the best results in the viability experiments, as expressed as an apoptosis/proliferation ratio < 1. We also looked at other materials, such as native silicon-oxide (SiO2) and borosilicate glass. In the near future other (combinations) of microchip materials will be analyzed for their viability as well as analyzing the effect of mammalian cells on microchip materials in more detail with MALDI-MS. Copyright © 2005 by the Transducer Research Foundation, Inc.
Original languageEnglish
Title of host publicationProceedings of the 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2005), 9-13 October 2005, Boston, Massachussetts
Place of PublicationSan Diego
PublisherTransducer Research Foundation
ISBN (Print)978-097436111-6
Publication statusPublished - 2005
Externally publishedYes


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