Evaluation of the Ves-Matic Cube 200 erythrocyte sedimentation method : comparison with Westergren-based methods

J. Curvers, J. Kooren, M. Laan, E. Lierop, van, D.H. Kerkhof, van de, V. Scharnhorst, M. Herruer

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Abstract

The erythrocyte sedimentation rate (ESR) is still a widely used parameter for acute phase inflammation. Recently, new methods based on direct undiluted measurement of ESR in a standard EDTA tube have been developed. We evaluated the analytic performance of one of these new methods, the Ves-Matic Cube 200 (Diesse Diagnostica Senese, Siena, Italy), and compared it with several established Westergren-based diluted methods. The Ves-Matic Cube 200 showed a poor correlation (r = 0.83) with the International Council for Standardization in Haematology Westergren reference method, mainly caused by a considerable negative bias at low ESR levels. Moreover, a random bias was found at higher ESR levels that correlated with hematocrit levels, suggesting a differential influence of packed cell volume on the Ves-Matic Cube 200 results compared with Westergren results. We conclude that the Ves-Matic Cube 200 method is not interchangeable with Westergren-based diluted methods and generates ESR results that are too deviant to be clinically acceptable.
Original languageEnglish
Pages (from-to)653-660
JournalAmerican Journal of Clinical Pathology
Volume134
Issue number4
DOIs
Publication statusPublished - 2010

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