Abstract
To evaluate in vivo performance of hydroxylapatite cement (HAC) as a porous bone graft substitute, HAC was mixed (1:1 volume ratio) with either porous calcium phosphate GRANULES (80% TCP, 20% HA) or defatted morsellized cancellous bone allograft (MCB) and implanted bilaterally in rabbit distal femurs. Groups with EMPTY defects and impacted MCB were used for reference. After eight weeks, one femur from each pair was examined histologically. Contralateral specimens and time-zero specimens were used for mechanical indentation tests. Histology showed that the EMPTY defects were filled with newly formed osteopenic bone after eight weeks. The MCB defects showed complete remodelling of graft into vital bone. Incorporation of the HAC/MCB composites was extensive but not completed, while minimal new bone ingrowth into the HAC/GRANULE composites was found. Indentation tests showed that both cement composites were significantly stronger than EMPTY defects, incorporated MCB and intact bone. Composites of HAC and porous biomaterials can maintain their relatively high strength over eight weeks in vivo, but their incorporation into a new bony structure is slowed by the synthetic materials. The HAC/MCB composite showed more favourable strength and incorporation.
Original language | English |
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Pages (from-to) | 221-224 |
Number of pages | 4 |
Journal | Key Engineering Materials |
Volume | 254-256 |
Publication status | Published - 9 Jan 2004 |
Externally published | Yes |
Event | The Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal Duration: 6 Nov 2003 → 9 Nov 2003 |
Keywords
- Bone graft
- Bone graft sustitute
- Cancellous
- Hydroxylapatite cement
- Incorporation