Evaluation of cardiac energetics by non-invasive 31P magnetic resonance spectroscopy

Desiree Abdurrachim, Jeanine J. Prompers

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Alterations in myocardial energy metabolism have been implicated in the pathophysiology of cardiac diseases such as heart failure and diabetic cardiomyopathy. 31P magnetic resonance spectroscopy (MRS) is a powerful tool to investigate cardiac energetics non-invasively in vivo, by detecting phosphorus ( 31P)-containing metabolites involved in energy supply and buffering. In this article, we review the historical development of cardiac 31P MRS, the readouts used to assess cardiac energetics from 31P MRS, and how 31P MRS studies have contributed to the understanding of cardiac energy metabolism in heart failure and diabetes. This article is part of a Special issue entitled Cardiac adaptations to obesity, diabetes and insulin resistance, edited by Professors Jan F.C. Glatz, Jason R.B. Dyck and Christine Des Rosiers.

Original languageEnglish
Pages (from-to)1939-1948
Number of pages10
JournalBiochimica et Biophysica Acta, Molecular Basis of Disease
Volume1864
Issue number5, Part B
DOIs
Publication statusPublished - May 2018

Keywords

  • P magnetic resonance spectroscopy
  • Cardiac energetics
  • Creatine kinase
  • Diabetes
  • Heart
  • Heart failure
  • Phosphorus Isotopes
  • Diabetic Cardiomyopathies/metabolism
  • Heart Failure/metabolism
  • Humans
  • Creatine Kinase/metabolism
  • Adenosine Triphosphate/metabolism
  • Biomarkers/metabolism
  • Phosphocreatine/metabolism
  • Magnetic Resonance Spectroscopy/methods
  • Animals
  • Myocardial Ischemia/metabolism
  • Energy Metabolism
  • Myocardium/metabolism
  • P-31 magnetic resonance spectroscopy

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