Estimation of left ventricular pressure with the pump as “sensor” in patients with a continuous flow LVAD

K.A.M.A. Pennings, S. van Tuijl, F.N. van de Vosse, B.A.J.M. de Mol, M.C.M. Rutten

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
3 Downloads (Pure)

Abstract

Introduction: In long-term ventricular support of patients with LVADs, left ventricular pressure (plv) is relevant for indicating the unloading level of the heart. Monitoring of plv over time might give more insight into the increase or decrease in native ventricular function. In this study, we aim to assess dynamic plv noninvasively, using the LVAD as a pressure sensor. Methods: Pressure head (dplvad) was estimated from pump flow with a dynamic pump model (1). Estimated dplvad and measured aortic pressure were used to calculate left ventricular pressure. Moreover, parameters dp/dtmax and mean, minimum, and maximum plv were derived. The method was validated with a porcine ex vivo beating heart model by measurements conducted in 4 hearts supported with a Micromed DeBakey VAD and 3 hearts with a Heartmate II VAD. During each measurement, aortic and left ventricular pressure, pump flow, and pressure head were recorded for 30 s with a sampling frequency of 1 kHz. Results: The estimation of left ventricular pressure appeared to be accurate for both pumps. The parameters mean and minimum pressure were estimated with high accuracy. The degree of accuracy of the estimated plv was proportional to the degree of accuracy of the dynamic pump model. Conclusions: We proved that the LVAD model described in this paper can be used as a pressure indicator to determine LV pressure at any time based on noninvasive measurements of pump flow, aortic pressure, and the properties of the outlet graft.

Original languageEnglish
Pages (from-to)433-443
Number of pages11
JournalInternational Journal of Artificial Organs
Volume38
Issue number8
DOIs
Publication statusPublished - 1 Aug 2015

Fingerprint

Ventricular Pressure
Pumps
Pressure
Sensors
Arterial Pressure
Ventricular Function
Swine
Transplants
Pressure sensors
Unloading
Grafts
Sampling

Keywords

  • Left ventricular assist device
  • Left ventricular function
  • Left ventricular pressure
  • LVAD
  • Pump characteristics

Cite this

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title = "Estimation of left ventricular pressure with the pump as “sensor” in patients with a continuous flow LVAD",
abstract = "Introduction: In long-term ventricular support of patients with LVADs, left ventricular pressure (plv) is relevant for indicating the unloading level of the heart. Monitoring of plv over time might give more insight into the increase or decrease in native ventricular function. In this study, we aim to assess dynamic plv noninvasively, using the LVAD as a pressure sensor. Methods: Pressure head (dplvad) was estimated from pump flow with a dynamic pump model (1). Estimated dplvad and measured aortic pressure were used to calculate left ventricular pressure. Moreover, parameters dp/dtmax and mean, minimum, and maximum plv were derived. The method was validated with a porcine ex vivo beating heart model by measurements conducted in 4 hearts supported with a Micromed DeBakey VAD and 3 hearts with a Heartmate II VAD. During each measurement, aortic and left ventricular pressure, pump flow, and pressure head were recorded for 30 s with a sampling frequency of 1 kHz. Results: The estimation of left ventricular pressure appeared to be accurate for both pumps. The parameters mean and minimum pressure were estimated with high accuracy. The degree of accuracy of the estimated plv was proportional to the degree of accuracy of the dynamic pump model. Conclusions: We proved that the LVAD model described in this paper can be used as a pressure indicator to determine LV pressure at any time based on noninvasive measurements of pump flow, aortic pressure, and the properties of the outlet graft.",
keywords = "Left ventricular assist device, Left ventricular function, Left ventricular pressure, LVAD, Pump characteristics",
author = "K.A.M.A. Pennings and {van Tuijl}, S. and {van de Vosse}, F.N. and {de Mol}, B.A.J.M. and M.C.M. Rutten",
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Estimation of left ventricular pressure with the pump as “sensor” in patients with a continuous flow LVAD. / Pennings, K.A.M.A.; van Tuijl, S.; van de Vosse, F.N.; de Mol, B.A.J.M.; Rutten, M.C.M.

In: International Journal of Artificial Organs, Vol. 38, No. 8, 01.08.2015, p. 433-443.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Estimation of left ventricular pressure with the pump as “sensor” in patients with a continuous flow LVAD

AU - Pennings, K.A.M.A.

AU - van Tuijl, S.

AU - van de Vosse, F.N.

AU - de Mol, B.A.J.M.

AU - Rutten, M.C.M.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Introduction: In long-term ventricular support of patients with LVADs, left ventricular pressure (plv) is relevant for indicating the unloading level of the heart. Monitoring of plv over time might give more insight into the increase or decrease in native ventricular function. In this study, we aim to assess dynamic plv noninvasively, using the LVAD as a pressure sensor. Methods: Pressure head (dplvad) was estimated from pump flow with a dynamic pump model (1). Estimated dplvad and measured aortic pressure were used to calculate left ventricular pressure. Moreover, parameters dp/dtmax and mean, minimum, and maximum plv were derived. The method was validated with a porcine ex vivo beating heart model by measurements conducted in 4 hearts supported with a Micromed DeBakey VAD and 3 hearts with a Heartmate II VAD. During each measurement, aortic and left ventricular pressure, pump flow, and pressure head were recorded for 30 s with a sampling frequency of 1 kHz. Results: The estimation of left ventricular pressure appeared to be accurate for both pumps. The parameters mean and minimum pressure were estimated with high accuracy. The degree of accuracy of the estimated plv was proportional to the degree of accuracy of the dynamic pump model. Conclusions: We proved that the LVAD model described in this paper can be used as a pressure indicator to determine LV pressure at any time based on noninvasive measurements of pump flow, aortic pressure, and the properties of the outlet graft.

AB - Introduction: In long-term ventricular support of patients with LVADs, left ventricular pressure (plv) is relevant for indicating the unloading level of the heart. Monitoring of plv over time might give more insight into the increase or decrease in native ventricular function. In this study, we aim to assess dynamic plv noninvasively, using the LVAD as a pressure sensor. Methods: Pressure head (dplvad) was estimated from pump flow with a dynamic pump model (1). Estimated dplvad and measured aortic pressure were used to calculate left ventricular pressure. Moreover, parameters dp/dtmax and mean, minimum, and maximum plv were derived. The method was validated with a porcine ex vivo beating heart model by measurements conducted in 4 hearts supported with a Micromed DeBakey VAD and 3 hearts with a Heartmate II VAD. During each measurement, aortic and left ventricular pressure, pump flow, and pressure head were recorded for 30 s with a sampling frequency of 1 kHz. Results: The estimation of left ventricular pressure appeared to be accurate for both pumps. The parameters mean and minimum pressure were estimated with high accuracy. The degree of accuracy of the estimated plv was proportional to the degree of accuracy of the dynamic pump model. Conclusions: We proved that the LVAD model described in this paper can be used as a pressure indicator to determine LV pressure at any time based on noninvasive measurements of pump flow, aortic pressure, and the properties of the outlet graft.

KW - Left ventricular assist device

KW - Left ventricular function

KW - Left ventricular pressure

KW - LVAD

KW - Pump characteristics

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U2 - 10.5301/ijao.5000424

DO - 10.5301/ijao.5000424

M3 - Article

C2 - 26349533

AN - SCOPUS:84942315109

VL - 38

SP - 433

EP - 443

JO - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

SN - 0391-3988

IS - 8

ER -