Estimation of instantaneous flow from the indicator-dilution curve after bolus injection of indicator

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Abstract

The indicator-dilution technique is commonly used to determine mean flow estimates. The estimation of instantaneous flow from the shape of an indicator-dilution curve is the objective of this study. Based on a mixing chamber approach to the flow system, a mathematical relationship is derived to reconstruct momentary flow from an indicator-dilution curve. This relationship is verified in a model setup both with only constant flow and with a sinusoidal flow variation superimposed. This method proved to give good flow estimates for limited values of flow parameters. Also, some preliminary experiments were performed in a pulsating flow system simulating heart action. The results were promising although the method proved to be very sensitive to baseline offset.
Original languageEnglish
Pages (from-to)51-56
JournalMedical and Biological Engineering and Computing
Volume25
Issue number1
DOIs
Publication statusPublished - 1987

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