Estimating B1+ in the breast at 7 T using a generic template

M.J. van Rijssel, J.P.W. Pluim, P.R. Luijten, K.G.A. Gilhuijs, A.W.J. Raaijmakers, D.W.J. Klomp

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Abstract

Dynamic contrast-enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B1+) field inhomogeneities. B1+field information is required in order to correct these. The use of a generic, coil-specific B1+template is proposed and tested. Finite-difference time-domain simulations for B1+were performed for healthy female volunteers with a wide range of breast anatomies. A generic B1+template was constructed by averaging simulations based on four volunteers. Three-dimensional B1+maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B1+mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values (% of nominal flip angle) comparing individual simulations with the template were in the range 2.00-4.01%, with mean 2.68%. RMSE values comparing individual measurements with the template were in the range8.1-16%, with mean 11.7%. The agreement between the proposed template approach and a B1+mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16% of the nominal angle for repeated measurement to ±22% for the B1+template. With local RF transmit coils, intersubject differences in B1+fields of the breast are comparable to the accuracy of B1+mapping methods, even at 7 T. Consequently, a single generic B1+template suits subjects over a wide range of breast anatomies, eliminating the need for a time-consuming B1+mapping protocol.

Original languageEnglish
Article numbere3911
Number of pages12
JournalNMR in Biomedicine
Volume31
Issue number5
Early online date23 Mar 2018
DOIs
Publication statusPublished - 1 May 2018

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Breast
Volunteers
Mean square error
Anatomy
Magnetic resonance imaging
Healthy Volunteers

Keywords

  • Journal Article

Cite this

van Rijssel, M. J., Pluim, J. P. W., Luijten, P. R., Gilhuijs, K. G. A., Raaijmakers, A. W. J., & Klomp, D. W. J. (2018). Estimating B1+ in the breast at 7 T using a generic template. NMR in Biomedicine, 31(5), [e3911]. https://doi.org/10.1002/nbm.3911
van Rijssel, M.J. ; Pluim, J.P.W. ; Luijten, P.R. ; Gilhuijs, K.G.A. ; Raaijmakers, A.W.J. ; Klomp, D.W.J. / Estimating B1+ in the breast at 7 T using a generic template. In: NMR in Biomedicine. 2018 ; Vol. 31, No. 5.
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abstract = "Dynamic contrast-enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B1+) field inhomogeneities. B1+field information is required in order to correct these. The use of a generic, coil-specific B1+template is proposed and tested. Finite-difference time-domain simulations for B1+were performed for healthy female volunteers with a wide range of breast anatomies. A generic B1+template was constructed by averaging simulations based on four volunteers. Three-dimensional B1+maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B1+mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values ({\%} of nominal flip angle) comparing individual simulations with the template were in the range 2.00-4.01{\%}, with mean 2.68{\%}. RMSE values comparing individual measurements with the template were in the range8.1-16{\%}, with mean 11.7{\%}. The agreement between the proposed template approach and a B1+mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16{\%} of the nominal angle for repeated measurement to ±22{\%} for the B1+template. With local RF transmit coils, intersubject differences in B1+fields of the breast are comparable to the accuracy of B1+mapping methods, even at 7 T. Consequently, a single generic B1+template suits subjects over a wide range of breast anatomies, eliminating the need for a time-consuming B1+mapping protocol.",
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Estimating B1+ in the breast at 7 T using a generic template. / van Rijssel, M.J.; Pluim, J.P.W.; Luijten, P.R.; Gilhuijs, K.G.A.; Raaijmakers, A.W.J.; Klomp, D.W.J.

In: NMR in Biomedicine, Vol. 31, No. 5, e3911, 01.05.2018.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - van Rijssel, M.J.

AU - Pluim, J.P.W.

AU - Luijten, P.R.

AU - Gilhuijs, K.G.A.

AU - Raaijmakers, A.W.J.

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N2 - Dynamic contrast-enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B1+) field inhomogeneities. B1+field information is required in order to correct these. The use of a generic, coil-specific B1+template is proposed and tested. Finite-difference time-domain simulations for B1+were performed for healthy female volunteers with a wide range of breast anatomies. A generic B1+template was constructed by averaging simulations based on four volunteers. Three-dimensional B1+maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B1+mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values (% of nominal flip angle) comparing individual simulations with the template were in the range 2.00-4.01%, with mean 2.68%. RMSE values comparing individual measurements with the template were in the range8.1-16%, with mean 11.7%. The agreement between the proposed template approach and a B1+mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16% of the nominal angle for repeated measurement to ±22% for the B1+template. With local RF transmit coils, intersubject differences in B1+fields of the breast are comparable to the accuracy of B1+mapping methods, even at 7 T. Consequently, a single generic B1+template suits subjects over a wide range of breast anatomies, eliminating the need for a time-consuming B1+mapping protocol.

AB - Dynamic contrast-enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B1+) field inhomogeneities. B1+field information is required in order to correct these. The use of a generic, coil-specific B1+template is proposed and tested. Finite-difference time-domain simulations for B1+were performed for healthy female volunteers with a wide range of breast anatomies. A generic B1+template was constructed by averaging simulations based on four volunteers. Three-dimensional B1+maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B1+mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values (% of nominal flip angle) comparing individual simulations with the template were in the range 2.00-4.01%, with mean 2.68%. RMSE values comparing individual measurements with the template were in the range8.1-16%, with mean 11.7%. The agreement between the proposed template approach and a B1+mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16% of the nominal angle for repeated measurement to ±22% for the B1+template. With local RF transmit coils, intersubject differences in B1+fields of the breast are comparable to the accuracy of B1+mapping methods, even at 7 T. Consequently, a single generic B1+template suits subjects over a wide range of breast anatomies, eliminating the need for a time-consuming B1+mapping protocol.

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