Equilibrium studies on enantioselective liquid - liquid amino acid extraction using a cinchona alkaloid extractant

B. Schuur, J.G.M. Winkelman, H.J. Heeres

Research output: Contribution to journalArticleAcademicpeer-review

83 Citations (Scopus)
1 Downloads (Pure)

Abstract

The enantioselective extraction of aqueous 3,5-dinitrobenzoyl-R,S-leucine (AR,S) by a cinchona alkaloid extractant (C) in 1,2-dichloroethane was studied at room temperature (294 K) in a batch system for a range of intake concentrations (10-4 - 10-3 mol/L) and pH values (3.8-6.6). The experimental data were described by a reactive extraction model with a homogeneous organic phase reaction of AR,S with C. Important parameters of this model were determined experimentally. The acid dissociation constant, Ka, of AR,S was (1.92 ± 0.07) x 10 -4 mol/L. The physical distribution coefficient of AR,S between the organic and aqueous phase was 8.04 ± 0.39. The equilibrium constants of the organic phase complexation reaction were (9.31 ± 0.76) x 104 L/mol and (2.71 ± 0.76) x 104 L/mol for the S- and R-enantiomers, respectively. With these parameters an optimum performance factor, PF, of 0.19 was predicted. The PF was independent of the pH provided that pH » pKa. The model was verified experimentally with excellent results (±7.9%).
Original languageEnglish
Pages (from-to)10027-10033
JournalIndustrial and Engineering Chemistry Research
Volume47
Issue number24
DOIs
Publication statusPublished - 2008

Fingerprint Dive into the research topics of 'Equilibrium studies on enantioselective liquid - liquid amino acid extraction using a cinchona alkaloid extractant'. Together they form a unique fingerprint.

  • Cite this