Enhancing the CuAAC efficiency of a Cu(i)-NHC complex in biological media by encapsulation

A. P. Prakasham; Harshit Singh; Anja R.A. Palmans

doi:10.1039/d5cc01891a

Enhancing the CuAAC efficiency of a Cu(i)-NHC complex in biological media by encapsulation

A. P. Prakasham (Corresponding author)
, Harshit Singh
, Anja R.A. Palmans (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

32 Downloads (Pure)

Abstract

A novel [(NHC)₂Cu]Br (Cu(i)-NHC) complex promotes CuAAC reactions in organic solvents, water, buffers and even complex biological media in good yields. Encapsulation of the Cu catalyst in an amphiphilic polymer enhances its performance in complex media, increases catalyst stability in the presence of glutathione and reduces cytotoxicity in HeLa cells.

Original language	English
Pages (from-to)	9697-9700
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	53
Early online date	20 May 2025
DOIs	https://doi.org/10.1039/d5cc01891a
Publication status	Published - 7 Jul 2025

Bibliographical note

Publisher Copyright:
© 2025 The Royal Society of Chemistry.

Funding

The project has received funding from the European Union’sHorizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 899987. We gratefully acknowledge support by The Dutch Research Council (NWO Gravitation; IPM program), the TU/e and Peter Lipmanfor ICP-OES analysis.

Keywords

Copper/chemistry
Humans
HeLa Cells
Coordination Complexes/chemistry
Glutathione/chemistry
Catalysis
Cell Survival/drug effects
Antineoplastic Agents/chemistry
Cycloaddition Reaction

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abstract = "A novel [(NHC)2Cu]Br (Cu(i)-NHC) complex promotes CuAAC reactions in organic solvents, water, buffers and even complex biological media in good yields. Encapsulation of the Cu catalyst in an amphiphilic polymer enhances its performance in complex media, increases catalyst stability in the presence of glutathione and reduces cytotoxicity in HeLa cells.",

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AU - Singh, Harshit

AU - Palmans, Anja R.A.

PY - 2025/7/7

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AB - A novel [(NHC)2Cu]Br (Cu(i)-NHC) complex promotes CuAAC reactions in organic solvents, water, buffers and even complex biological media in good yields. Encapsulation of the Cu catalyst in an amphiphilic polymer enhances its performance in complex media, increases catalyst stability in the presence of glutathione and reduces cytotoxicity in HeLa cells.

KW - Copper/chemistry

KW - Humans

KW - HeLa Cells

KW - Coordination Complexes/chemistry

KW - Glutathione/chemistry

KW - Catalysis

KW - Cell Survival/drug effects

KW - Antineoplastic Agents/chemistry

KW - Cycloaddition Reaction

UR - https://www.scopus.com/pages/publications/105008081589

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EP - 9700

JO - Chemical Communications

JF - Chemical Communications

IS - 53

ER -

Enhancing the CuAAC efficiency of a Cu(i)-NHC complex in biological media by encapsulation

Abstract

Bibliographical note

Funding

Keywords

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