Engineering tissue morphogenesis: taking it up a Notch

Laura A. Tiemeijer; Sami Sanlidag; Carlijn V.C. Bouten; Cecilia M Sahlgren

doi:10.1016/j.tibtech.2022.01.007

Engineering tissue morphogenesis: taking it up a Notch

Laura A. Tiemeijer, Sami Sanlidag, Carlijn V.C. Bouten (Corresponding author), Cecilia M Sahlgren (Corresponding author)

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

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Abstract

Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

Original language	English
Pages (from-to)	945-957
Number of pages	13
Journal	Trends in Biotechnology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1016/j.tibtech.2022.01.007
Publication status	Published - Aug 2022

Funding

This research was supported by the InFLAMES Flagship Programme of the Academy of Finland (decision 337530 ) (L.A.T., S.S., C.S.), the Academy of Finland ( 316882 , 330411 ) (S.S., C.S.), the European Research Council (ERC) under the EU Horizon 2020 Research and Innovation Programme (grant 771168 ) (C.S.) as well as the Åbo Akademi University Foundation Centers of Excellence in Cellular Mechanostasis and Bioelectronic Activation of Cell Functions (C.S.) and the Gravitation Program 'Materials Driven Regeneration' funded by the Netherlands Organization for Scientific Research ( 024.003.013 ) (C.B.). The figures in this article were created with BioRender.com .

Funders	Funder number
European Union's Horizon 2020 - Research and Innovation Framework Programme
H2020 European Research Council
Academy of Finland	337530, 330411, 316882
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	024.003.013
Horizon 2020	771168
Åbo Akademi University

Keywords

ligand immobilization
morphogenesis
Notch signaling
Notch signaling modulation
tissue patterning

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title = "Engineering tissue morphogenesis: taking it up a Notch",

abstract = "Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.",

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AU - Sanlidag, Sami

AU - Bouten, Carlijn V.C.

AU - Sahlgren, Cecilia M

PY - 2022/8

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AB - Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

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KW - morphogenesis

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JO - Trends in Biotechnology

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Engineering tissue morphogenesis: taking it up a Notch

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