Engineering Organ-on-a-Chip to Accelerate Translational Research

Jihoon Ko; Dohyun Park; Somin Lee; Burcu Gumuscu; Noo Li Jeon

doi:10.3390/mi13081200

Engineering Organ-on-a-Chip to Accelerate Translational Research

Jihoon Ko, Dohyun Park, Somin Lee, Burcu Gumuscu, Noo Li Jeon (Corresponding author)

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

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Abstract

We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments. The organ-on-chip platform consists of microfluidic channels, cell culture chambers, and stimulus sources that emulate the in-vivo microenvironment. These platforms are typically engraved into an oxygen-permeable transparent material. Fabrication of these materials requires the use of microfabrication strategies, including soft lithography, 3D printing, and injection molding. Here we provide an overview of what is an organ-on-chip platform, where it can be used, what it is composed of, how it can be fabricated, and how it can be operated. In connection with this topic, we also introduce an overview of the recent applications, where different organs are modeled on the microscale using this technology.

Original language	English
Article number	1200
Number of pages	25
Journal	Micromachines
Volume	13
Issue number	8
DOIs	https://doi.org/10.3390/mi13081200
Publication status	Published - Aug 2022

Bibliographical note

Funding Information:
This work was funded by grants from the National Research Foundation (NRF) of Korea [2021R1A3B1077481] awarded to N.L. Jeon and the Bio & Medical Technology Development Program of the NRF funded by K-BIO KIURI Center through the Ministry of Science and ICT (MSIT) [2020M3H1A1073304] awarded to D. Park. B.G. acknowledges the support of NWO Gravitation Fund on interactive polymer materials and the support of the institute of complex molecular systems at the Eindhoven University of Technology.

Funding

This work was funded by grants from the National Research Foundation (NRF) of Korea [2021R1A3B1077481] awarded to N.L. Jeon and the Bio & Medical Technology Development Program of the NRF funded by K-BIO KIURI Center through the Ministry of Science and ICT (MSIT) [2020M3H1A1073304] awarded to D. Park. B.G. acknowledges the support of NWO Gravitation Fund on interactive polymer materials and the support of the institute of complex molecular systems at the Eindhoven University of Technology.

Keywords

biochemical stimuli
biophysical stimuli
in vitro cell culture
microfabrication
microphysiological system
organ-on-a-chip

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abstract = "We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments. The organ-on-chip platform consists of microfluidic channels, cell culture chambers, and stimulus sources that emulate the in-vivo microenvironment. These platforms are typically engraved into an oxygen-permeable transparent material. Fabrication of these materials requires the use of microfabrication strategies, including soft lithography, 3D printing, and injection molding. Here we provide an overview of what is an organ-on-chip platform, where it can be used, what it is composed of, how it can be fabricated, and how it can be operated. In connection with this topic, we also introduce an overview of the recent applications, where different organs are modeled on the microscale using this technology.",

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note = "Funding Information: This work was funded by grants from the National Research Foundation (NRF) of Korea [2021R1A3B1077481] awarded to N.L. Jeon and the Bio & Medical Technology Development Program of the NRF funded by K-BIO KIURI Center through the Ministry of Science and ICT (MSIT) [2020M3H1A1073304] awarded to D. Park. B.G. acknowledges the support of NWO Gravitation Fund on interactive polymer materials and the support of the institute of complex molecular systems at the Eindhoven University of Technology. ",

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Engineering Organ-on-a-Chip to Accelerate Translational Research

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