Engineered protein cages for selective heparin encapsulation

Salla Välimäki, Qing Liu, Lise Schoonen, Daan F.M. Vervoort, Nonappa, Veikko Linko, Roeland J.M. Nolte, Jan C.M. van Hest, Mauri A. Kostiainen (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

Original languageEnglish
Pages (from-to)1272-1276
Number of pages5
JournalJournal of Materials Chemistry B
Volume9
Issue number5
DOIs
Publication statusPublished - 7 Feb 2021

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