Engineered protein cages for selective heparin encapsulation

Salla Välimäki, Qing Liu, Lise Schoonen, Daan F.M. Vervoort, Nonappa, Veikko Linko, Roeland J.M. Nolte, Jan C.M. van Hest, Mauri A. Kostiainen (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

Original languageEnglish
Pages (from-to)1272-1276
Number of pages5
JournalJournal of Materials Chemistry B
Volume9
Issue number5
DOIs
Publication statusPublished - 7 Feb 2021

Funding

We gratefully thank the Academy of Finland (projects 308578, 303804, 267497), the Jane and Aatos Erkko Foundation, the Sigrid Jusélius Foundation and the Emil Aaltonen Foundation for financial support. We acknowledge the provision of facilities at OtaNano – Nanomicroscopy Center (Aalto-NMC) and Bioeconomy Infrastructure. Support was also received from the European Research Council (ERC Advanced Grant 740295 ENCOPOL to R. J. M. N.) and from the Dutch Ministry of Education, Culture

FundersFunder number
Dutch Ministry of Education, Culture, and Science
Horizon 2020 Framework Programme740295
European Research Council
Academy of Finland303804, 267497, 308578
Ministerie van Onderwijs, Cultuur en Wetenschap024.001.035
Jane ja Aatos Erkon Säätiö

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