Engineered protein cages for selective heparin encapsulation

Salla Välimäki; Qing Liu; Lise Schoonen; Daan F.M. Vervoort; Nonappa; Veikko Linko; Roeland J.M. Nolte; Jan C.M. van Hest; Mauri A. Kostiainen

doi:10.1039/d0tb02541k

Engineered protein cages for selective heparin encapsulation

Salla Välimäki, Qing Liu, Lise Schoonen, Daan F.M. Vervoort, Nonappa, Veikko Linko, Roeland J.M. Nolte, Jan C.M. van Hest, Mauri A. Kostiainen (Corresponding author)

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13 Citations (Scopus)

Abstract

A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

Original language	English
Pages (from-to)	1272-1276
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	9
Issue number	5
DOIs	https://doi.org/10.1039/d0tb02541k
Publication status	Published - 7 Feb 2021

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abstract = "A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.",

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T1 - Engineered protein cages for selective heparin encapsulation

AU - Välimäki, Salla

AU - Liu, Qing

AU - Schoonen, Lise

AU - Vervoort, Daan F.M.

AU - Nonappa,

AU - Linko, Veikko

AU - Nolte, Roeland J.M.

AU - van Hest, Jan C.M.

AU - Kostiainen, Mauri A.

PY - 2021/2/7

Y1 - 2021/2/7

N2 - A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

AB - A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

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U2 - 10.1039/d0tb02541k

DO - 10.1039/d0tb02541k

M3 - Article

C2 - 33427277

AN - SCOPUS:85101484073

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VL - 9

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JF - Journal of Materials Chemistry B

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ER -

Engineered protein cages for selective heparin encapsulation

Abstract

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