Encoded dendrimers with defined chiral composition via 'click' reaction of enantiopure building blocks

B. Yeniad; H. Naik; R.J. Amir; C.E. Koning; C.J. Hawker; A. Heise

doi:10.1039/c1cc12434j

Encoded dendrimers with defined chiral composition via 'click' reaction of enantiopure building blocks

B. Yeniad, H. Naik, R.J. Amir, C.E. Koning, C.J. Hawker, A. Heise

Chemical Engineering and Chemistry

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

Dendrimers with end-groups of defined chiral composition have been prepared from alkyne functional enantio-pure building blocks obtained by selective enzymatic (ADH) ketone reductions using click chemistry. Optical rotation and enantioselective enzymatic modification is in agreement with the chiral composition of the dendrimers and permits unique molecular-level encoding of stereoisomeric dendritic libraries.

Original language	English
Pages (from-to)	9870-9872
Journal	Chemical Communications
Volume	47
Issue number	35
DOIs	https://doi.org/10.1039/c1cc12434j
Publication status	Published - 2011

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abstract = "Dendrimers with end-groups of defined chiral composition have been prepared from alkyne functional enantio-pure building blocks obtained by selective enzymatic (ADH) ketone reductions using click chemistry. Optical rotation and enantioselective enzymatic modification is in agreement with the chiral composition of the dendrimers and permits unique molecular-level encoding of stereoisomeric dendritic libraries.",

author = "B. Yeniad and H. Naik and R.J. Amir and C.E. Koning and C.J. Hawker and A. Heise",

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AU - Yeniad, B.

AU - Naik, H.

AU - Amir, R.J.

AU - Koning, C.E.

AU - Hawker, C.J.

AU - Heise, A.

PY - 2011

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AB - Dendrimers with end-groups of defined chiral composition have been prepared from alkyne functional enantio-pure building blocks obtained by selective enzymatic (ADH) ketone reductions using click chemistry. Optical rotation and enantioselective enzymatic modification is in agreement with the chiral composition of the dendrimers and permits unique molecular-level encoding of stereoisomeric dendritic libraries.

U2 - 10.1039/c1cc12434j

DO - 10.1039/c1cc12434j

M3 - Article

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VL - 47

SP - 9870

EP - 9872

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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ER -