Abstract
Besides the stimuli responsive release, catalysis or phase transfer, the encapsulation behavior of the star polymers has been also successfully exploited for drug-delivery applications. For all these purposes, esp. for biomedical applications, well defined structures are required. Our group has recently reported the synthesis and the encapsulation properties of well defined 5-arm star-shaped poly(ethylene glycol)-b-poly(a-caprolactone)s that present good encapsulation capabilities and even more they are able to transport guest mols. within biphasic systems. Here we report the encapsulation properties of the reversed systems with a hydrophobic core and a hydrophilic shell using disperse red 1 as model guest mol. The encapsulation abilities of these amphiphilic nancontainers have been evaluated by probing the changes in the microenvironment of the poor water sol. guest mols. using UV/Vis spectroscopy. The bathochromic shift from 420 to 512 nm of the intensity maxima in the absorption spectra of aq. solns. of different nanocontainer/disperse red 1 contents evidences the host-guest interactions. [on SciFinder (R)]
| Original language | English |
|---|---|
| Title of host publication | Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States |
| Place of Publication | Washington, D. C |
| Publisher | American Chemical Society |
| Pages | PMSE-425 |
| Publication status | Published - 2008 |
| Event | 235th ACS National Meeting - New Orleans, United States Duration: 6 Apr 2008 → 10 Apr 2008 |
Conference
| Conference | 235th ACS National Meeting |
|---|---|
| Country | United States |
| City | New Orleans |
| Period | 6/04/08 → 10/04/08 |
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Cite this
Schramm, O. G., Meier, M. A. R., Hoogenboom, R., & Schubert, U. S. (2008). Encapsulation properties of amphiphilic nano-containers for drug delivery applications. In Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States (pp. PMSE-425). American Chemical Society.