Encapsulation properties of amphiphilic nano-containers for drug delivery applications

O.G. Schramm, M.A.R. Meier, R. Hoogenboom, U.S. Schubert

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

Abstract

Besides the stimuli responsive release, catalysis or phase transfer, the encapsulation behavior of the star polymers has been also successfully exploited for drug-delivery applications. For all these purposes, esp. for biomedical applications, well defined structures are required. Our group has recently reported the synthesis and the encapsulation properties of well defined 5-arm star-shaped poly(ethylene glycol)-b-poly(a-caprolactone)s that present good encapsulation capabilities and even more they are able to transport guest mols. within biphasic systems. Here we report the encapsulation properties of the reversed systems with a hydrophobic core and a hydrophilic shell using disperse red 1 as model guest mol. The encapsulation abilities of these amphiphilic nancontainers have been evaluated by probing the changes in the microenvironment of the poor water sol. guest mols. using UV/Vis spectroscopy. The bathochromic shift from 420 to 512 nm of the intensity maxima in the absorption spectra of aq. solns. of different nanocontainer/disperse red 1 contents evidences the host-guest interactions. [on SciFinder (R)]
Original languageEnglish
Title of host publicationAbstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States
Place of PublicationWashington, D. C
PublisherAmerican Chemical Society
PagesPMSE-425
Publication statusPublished - 2008
Event235th ACS National Meeting - New Orleans, United States
Duration: 6 Apr 200810 Apr 2008

Conference

Conference235th ACS National Meeting
CountryUnited States
CityNew Orleans
Period6/04/0810/04/08

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  • Cite this

    Schramm, O. G., Meier, M. A. R., Hoogenboom, R., & Schubert, U. S. (2008). Encapsulation properties of amphiphilic nano-containers for drug delivery applications. In Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States (pp. PMSE-425). American Chemical Society.