Encapsulation of guest molecules into a dendritic box

J.F.G.A. Jansen, E.M.M. Berg, van den, E.W. Meijer

    Research output: Contribution to journalArticleAcademicpeer-review

    1144 Citations (Scopus)

    Abstract

    Dendrimers are well-defined, highly branched macromols. that emanate from a central core and are synthesized through a stepwise, repetitive reaction sequence. The synthesis and characterization of dendritic boxes, based on the construction of a chiral shell of protected amino acids onto poly(propyleneimine) dendrimers with 64 amine end groups, is reported here. NMR-relaxation and optical data show that a dense shell with solid-phase character is formed. Guest mols. were captured within the internal cavities of the boxes when these boxes were constructed in the presence of guest mols. The diffusion of guest mols. out of the boxes into soln. was unmeasurably slow because of the close packing of the shell. These monomol. dendritic containers of 5-nm dimensions with phys. locked-in guest mols. were characterized spectroscopically. Guest mols. were captured within the internal cavities of the boxes when these boxes were constructed in the presence of guest mols. The diffusion of guest mols. out of the boxes into soln. was unmeasurably slow because of the close packing of the shell. These monomol. dendritic containers of 5-nm dimensions with phys. locked-in guest mols. were characterized spectroscopically. [on SciFinder (R)]
    LanguageEnglish
    Pages1226-1229
    JournalScience
    Volume266
    Issue number5188
    DOIs
    StatePublished - 1994

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    Dendrimers
    Encapsulation
    Containers
    Molecules
    Amines
    Nuclear magnetic resonance
    Amino Acids
    poly(propyleneimine)

    Cite this

    Jansen, J. F. G. A., Berg, van den, E. M. M., & Meijer, E. W. (1994). Encapsulation of guest molecules into a dendritic box. Science, 266(5188), 1226-1229. DOI: 10.1126/science.266.5188.1226
    Jansen, J.F.G.A. ; Berg, van den, E.M.M. ; Meijer, E.W./ Encapsulation of guest molecules into a dendritic box. In: Science. 1994 ; Vol. 266, No. 5188. pp. 1226-1229
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    Jansen, JFGA, Berg, van den, EMM & Meijer, EW 1994, 'Encapsulation of guest molecules into a dendritic box' Science, vol. 266, no. 5188, pp. 1226-1229. DOI: 10.1126/science.266.5188.1226

    Encapsulation of guest molecules into a dendritic box. / Jansen, J.F.G.A.; Berg, van den, E.M.M.; Meijer, E.W.

    In: Science, Vol. 266, No. 5188, 1994, p. 1226-1229.

    Research output: Contribution to journalArticleAcademicpeer-review

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    N2 - Dendrimers are well-defined, highly branched macromols. that emanate from a central core and are synthesized through a stepwise, repetitive reaction sequence. The synthesis and characterization of dendritic boxes, based on the construction of a chiral shell of protected amino acids onto poly(propyleneimine) dendrimers with 64 amine end groups, is reported here. NMR-relaxation and optical data show that a dense shell with solid-phase character is formed. Guest mols. were captured within the internal cavities of the boxes when these boxes were constructed in the presence of guest mols. The diffusion of guest mols. out of the boxes into soln. was unmeasurably slow because of the close packing of the shell. These monomol. dendritic containers of 5-nm dimensions with phys. locked-in guest mols. were characterized spectroscopically. Guest mols. were captured within the internal cavities of the boxes when these boxes were constructed in the presence of guest mols. The diffusion of guest mols. out of the boxes into soln. was unmeasurably slow because of the close packing of the shell. These monomol. dendritic containers of 5-nm dimensions with phys. locked-in guest mols. were characterized spectroscopically. [on SciFinder (R)]

    AB - Dendrimers are well-defined, highly branched macromols. that emanate from a central core and are synthesized through a stepwise, repetitive reaction sequence. The synthesis and characterization of dendritic boxes, based on the construction of a chiral shell of protected amino acids onto poly(propyleneimine) dendrimers with 64 amine end groups, is reported here. NMR-relaxation and optical data show that a dense shell with solid-phase character is formed. Guest mols. were captured within the internal cavities of the boxes when these boxes were constructed in the presence of guest mols. The diffusion of guest mols. out of the boxes into soln. was unmeasurably slow because of the close packing of the shell. These monomol. dendritic containers of 5-nm dimensions with phys. locked-in guest mols. were characterized spectroscopically. Guest mols. were captured within the internal cavities of the boxes when these boxes were constructed in the presence of guest mols. The diffusion of guest mols. out of the boxes into soln. was unmeasurably slow because of the close packing of the shell. These monomol. dendritic containers of 5-nm dimensions with phys. locked-in guest mols. were characterized spectroscopically. [on SciFinder (R)]

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    Jansen JFGA, Berg, van den EMM, Meijer EW. Encapsulation of guest molecules into a dendritic box. Science. 1994;266(5188):1226-1229. Available from, DOI: 10.1126/science.266.5188.1226