Enantioselective enzymatic modification of chiral block copolymers

B. Yeniad, H. Naik, C.E. Koning, A. Heise

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)


Block copolymers comprising blocks with pendant hydroxy groups of opposite chirality are synthesized by RAFT polymn. of (R)- and (S)-1-(4-vinylphenyl)ethanol (1R and 1S) as monomers. Initially, poly(styrene) macro-RAFT agents are chain-extended with both enantiomeric monomers to obtain poly(styrene-b-1R) and poly(styrene-b-1S) with controlled mol. wt. and low polydispersities. Enantioselective esterification with vinyl acetate by Candida Antarctica Lipase B (CALB) is only possible on the 1R-contg. block copolymer. This concept is extended to a series of chiral block copolymers poly(1R-b-1S) which, apart from their optical rotation, all behave like very similar homopolymers. By enzymic enantioselective esterification on the 1R-block, block copolymer structures were obtained.
Original languageEnglish
Pages (from-to)556-562
JournalMacromolecular Chemistry and Physics
Issue number5
Publication statusPublished - 2013


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