Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks

Rocio Bueno-Perez; Ana Martin-Calvo; Paula Gómez-Álvarez; Juan J. Gutiérrez-Sevillano; Patrick J. Merkling; Thijs J.H. Vlugt; Titus S. van Erp; David Dubbeldam; Sofia Calero

doi:10.1039/c4cc03745f

Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks

Rocio Bueno-Perez, Ana Martin-Calvo, Paula Gómez-Álvarez, Juan J. Gutiérrez-Sevillano, Patrick J. Merkling, Thijs J.H. Vlugt, Titus S. van Erp, David Dubbeldam, Sofia Calero

Research output: Contribution to journal › Article › Academic › peer-review

54 Citations (Scopus)

Abstract

This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.

Original language	English
Pages (from-to)	10849-10852
Number of pages	4
Journal	Chemical Communications, ChemComm
Volume	50
Issue number	74
DOIs	https://doi.org/10.1039/c4cc03745f
Publication status	Published - 18 Aug 2014
Externally published	Yes

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abstract = "This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.",

author = "Rocio Bueno-Perez and Ana Martin-Calvo and Paula G{\'o}mez-{\'A}lvarez and Guti{\'e}rrez-Sevillano, {Juan J.} and Merkling, {Patrick J.} and Vlugt, {Thijs J.H.} and {van Erp}, {Titus S.} and David Dubbeldam and Sofia Calero",

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AU - Bueno-Perez, Rocio

AU - Martin-Calvo, Ana

AU - Gómez-Álvarez, Paula

AU - Gutiérrez-Sevillano, Juan J.

AU - Merkling, Patrick J.

AU - Vlugt, Thijs J.H.

AU - van Erp, Titus S.

AU - Dubbeldam, David

AU - Calero, Sofia

PY - 2014/8/18

Y1 - 2014/8/18

N2 - This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.

AB - This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.

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U2 - 10.1039/c4cc03745f

DO - 10.1039/c4cc03745f

M3 - Article

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AN - SCOPUS:84906346198

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SP - 10849

EP - 10852

JO - Chemical Communications, ChemComm

JF - Chemical Communications, ChemComm

IS - 74

ER -

Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks

Abstract

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