Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks

Rocio Bueno-Perez, Ana Martin-Calvo, Paula Gómez-Álvarez, Juan J. Gutiérrez-Sevillano, Patrick J. Merkling, Thijs J.H. Vlugt, Titus S. van Erp, David Dubbeldam, Sofia Calero

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)


This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.

Original languageEnglish
Pages (from-to)10849-10852
Number of pages4
JournalChemical Communications, ChemComm
Issue number74
Publication statusPublished - 18 Aug 2014
Externally publishedYes


Dive into the research topics of 'Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks'. Together they form a unique fingerprint.

Cite this