Emerging role of USPIOs for MR imaging of atherosclerosis

M.E. Kooi, S. Heeneman, M.J.A.P. Daemen, J.M.A. Engelshoven, van, K.B.J.M. Cleutjens

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademic


    Atherosclerosis is an inflammatory disease of the arteries, which causes more than 19 million deaths worldwide every year. Most complications of atherosclerosis are caused by rupture of a vulnerable plaque. Currently, there are no imaging techniques available in clinical practice that can accurately identify a vulnerable plaque. There is an emerging role for Ultrasmall Super-paramagnetic Iron Oxide Particles (USPIOs) in MR imaging of atherosclerosis. This review will first give an update on the biology of atherosclerosis. Next, we will focus on the physicochemical properties of USPIOs and describe animal and human studies that showed USPIO uptake mainly in macrophages of atherosclerotic plaque, which could be detected as areas of focal signal loss in MR images. Novel superparamagnetic particles are currently being developed which enable visualization of other cell types and functions than macrophage uptake that are relevant for atherosclerosis. We conclude that USPIOs are a highly promising imaging tool for atherosclerosis and larger prospective studies are warranted to prove the value in daily clinical practice.
    Original languageEnglish
    Title of host publicationNanoparticles in biomedical imaging: emerging technologies and applications
    EditorsM. Modo, J.W.M. Bulte
    Place of PublicationBerlin
    ISBN (Print)978-0-387-72027-2
    Publication statusPublished - 2008

    Publication series

    NameFundamental Biomedical Technologies
    ISSN (Print)1559-7083


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