Emerging modes-of-action in drug discovery

Eric Valeur (Corresponding author), Frank Narjes, Christian Ottmann, Alleyn T. Plowright

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


An increasing focus on complex biology to cure diseases rather than merely treat symptoms has transformed how drug discovery can be approached. Instead of activating or blocking protein function, a growing repertoire of drug modalities can be leveraged or engineered to hijack cellular processes, such as translational regulation or degradation mechanisms. Drug hunters can therefore access a wider arsenal of modes-of-action to modulate biological processes and this review summarises these emerging strategies by highlighting the most representative examples of these approaches.

Original languageEnglish
Pages (from-to)1550-1568
Number of pages19
Issue number9
Publication statusPublished - 1 Oct 2019


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