Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers

Joris J. Haven; Matthew Hendrikx; Tanja Junkers; Pieter J. Leenaers; Theodora Tsompanoglou; Cyrille Boyer; Jiangtao Xu; Almar Postma; Graeme Moad

doi:10.1021/bk-2018-1284.ch004

Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers

Joris J. Haven, Matthew Hendrikx, Tanja Junkers, Pieter J. Leenaers, Theodora Tsompanoglou, Cyrille Boyer, Jiangtao Xu, Almar Postma, Graeme Moad

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

22 Citations (Scopus)

Abstract

This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.

Original language	English
Title of host publication	Reversible Deactivation Radical Polymerization
Subtitle of host publication	Mechanisms and Synthetic Methodologies
Editors	Nicolay V. Tsarevsky, Haifeng Gao, Krzysztof Matyjaszewski, Brent S. Sumerlin
Place of Publication	Washington, DC
Publisher	American Chemical Society
Pages	77-103
Number of pages	27
ISBN (Electronic)	9780841233171
ISBN (Print)	9780841233188
DOIs	https://doi.org/10.1021/bk-2018-1284.ch004
Publication status	Published - 1 Jan 2018

Publication series

Name	ACS Symposium Series
Volume	1284
ISSN (Print)	0097-6156
ISSN (Electronic)	1947-5918

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10.1021/bk-2018-1284.ch004

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Haven, J. J., Hendrikx, M., Junkers, T., Leenaers, P. J., Tsompanoglou, T., Boyer, C., Xu, J., Postma, A., & Moad, G. (2018). Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers. In N. V. Tsarevsky, H. Gao, K. Matyjaszewski, & B. S. Sumerlin (Eds.), Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies (pp. 77-103). (ACS Symposium Series; Vol. 1284). American Chemical Society. https://doi.org/10.1021/bk-2018-1284.ch004

Haven, Joris J. ; Hendrikx, Matthew ; Junkers, Tanja et al. / Elements of RAFT navigation : RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers. Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. editor / Nicolay V. Tsarevsky ; Haifeng Gao ; Krzysztof Matyjaszewski ; Brent S. Sumerlin. Washington, DC : American Chemical Society, 2018. pp. 77-103 (ACS Symposium Series).

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title = "Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers",

abstract = "This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.",

author = "Haven, {Joris J.} and Matthew Hendrikx and Tanja Junkers and Leenaers, {Pieter J.} and Theodora Tsompanoglou and Cyrille Boyer and Jiangtao Xu and Almar Postma and Graeme Moad",

year = "2018",

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doi = "10.1021/bk-2018-1284.ch004",

language = "English",

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series = "ACS Symposium Series",

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Haven, JJ, Hendrikx, M, Junkers, T, Leenaers, PJ, Tsompanoglou, T, Boyer, C, Xu, J, Postma, A & Moad, G 2018, Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers. in NV Tsarevsky, H Gao, K Matyjaszewski & BS Sumerlin (eds), Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. ACS Symposium Series, vol. 1284, American Chemical Society, Washington, DC, pp. 77-103. https://doi.org/10.1021/bk-2018-1284.ch004

Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers. / Haven, Joris J.; Hendrikx, Matthew; Junkers, Tanja et al.
Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. ed. / Nicolay V. Tsarevsky; Haifeng Gao; Krzysztof Matyjaszewski; Brent S. Sumerlin. Washington, DC: American Chemical Society, 2018. p. 77-103 (ACS Symposium Series; Vol. 1284).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AU - Haven, Joris J.

AU - Hendrikx, Matthew

AU - Junkers, Tanja

AU - Leenaers, Pieter J.

AU - Tsompanoglou, Theodora

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AU - Xu, Jiangtao

AU - Postma, Almar

AU - Moad, Graeme

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AB - This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.

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Haven JJ, Hendrikx M, Junkers T, Leenaers PJ, Tsompanoglou T, Boyer C et al. Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers. In Tsarevsky NV, Gao H, Matyjaszewski K, Sumerlin BS, editors, Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. Washington, DC: American Chemical Society. 2018. p. 77-103. (ACS Symposium Series). doi: 10.1021/bk-2018-1284.ch004

Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers

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