Elements of RAFT navigation: RAFT 20 years later: RAFT-synthesis of uniform, sequence-defined (co)polymers

Joris J. Haven, Matthew Hendrikx, Tanja Junkers, Pieter J. Leenaers, Theodora Tsompanoglou, Cyrille Boyer, Jiangtao Xu, Almar Postma, Graeme Moad

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

22 Citations (Scopus)


This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.

Original languageEnglish
Title of host publicationReversible Deactivation Radical Polymerization
Subtitle of host publicationMechanisms and Synthetic Methodologies
EditorsNicolay V. Tsarevsky, Haifeng Gao, Krzysztof Matyjaszewski, Brent S. Sumerlin
Place of PublicationWashington, DC
PublisherAmerican Chemical Society
Number of pages27
ISBN (Electronic)9780841233171
ISBN (Print)9780841233188
Publication statusPublished - 1 Jan 2018

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918


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