Electromechanical wavebreak in a model of the human left ventricle

R.H. Keldermann, M.P. Nash, H. Gelderblom, V.Y. Wang, A.V. Panfilov

Research output: Contribution to journalArticleAcademicpeer-review

82 Citations (Scopus)

Abstract

In the present report, we introduce an integrative three-dimensional electromechanical model of the left ventricle of the human heart. Electrical activity is represented by the ionic TP06 model for human cardiac cells, and mechanical activity is represented by the Niederer-Hunter-Smith active contractile tension model and the exponential Guccione passive elasticity model. These models were embedded into an anatomic model of the left ventricle that contains a detailed description of cardiac geometry and the fiber orientation field. We demonstrated that fiber shortening and wall thickening during normal excitation were qualitatively similar to experimental recordings. We used this model to study the effect of mechanoelectrical feedback via stretch-activated channels on the stability of reentrant wave excitation. We found that mechanoelectrical feedback can induce the deterioration of an otherwise stable spiral wave into turbulent wave patterns similar to that of ventricular fibrillation. We identified the mechanisms of this transition and studied the three-dimensional organization of this mechanically induced ventricular fibrillation.

Original languageEnglish
Pages (from-to)H134-H143
JournalAmerican Journal of Physiology : Heart and Circulatory Physiology
Volume299
Issue number1
DOIs
Publication statusPublished - 1 Jul 2010

Keywords

  • Computer simulations
  • Electrophysiology
  • Mechanics
  • Mechanoelectrical feedback
  • Stretch-activated channels
  • Ventricular fibrillation

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