Elastin in vascular grafts

Richard Wang, Bente de Kort, Anthal Smits, Anthony Weiss

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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The clinical demand for a superior vascular graft is rising due to the increase in cardiovascular disease with an aging population. Despite decades of research, clinically translatable solutions remain limited. Recent progress in vascular graft engineering has highlighted the significance of biological integration for the success of implanted grafts. Thus there has been an increase in the usage of biological materials in vascular graft manufacture. Elastin, a natural protein that makes up a significant portion of the natural vascular extracellular matrix, has been demonstrated to be particularly important with both mechanical and biological modulatory roles. Progress in understanding elastogenesis, the process by which elastin is naturally synthesized, and increased access to synthetic elastin-based materials, has increased the usage of elastin in vascular graft engineering. In this chapter, we explore recent advances in the utilization of elastin as a material for vascular graft engineering. In particular, we focus on the myriad of methods which incorporate elastin into vascular grafts which demonstrate superior biological functionality and closer resemblance to native blood vessels.
Original languageEnglish
Title of host publicationTissue-Engineered Vascular Grafts
EditorsBeat Walpoth, Helga Bergmeister, Gary Bowlin, Deling Kong, Joris Rotmans, Peter Zilla
Place of PublicationCham
PublisherSpringer Nature
ISBN (Electronic)978-3-319-71530-8
Publication statusPublished - 27 Aug 2019

Publication series

NameReference Series in Biomedical Engineering


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