Elastin-based side-chain polymers synthesized by ATRP

L. Ayres; M.R.J. Vos; P.J.H.M. Adams; I.O. Shklyarevskiy; J.C.M. Hest, van

doi:10.1021/ma025727h

Elastin-based side-chain polymers synthesized by ATRP

L. Ayres, M.R.J. Vos, P.J.H.M. Adams, I.O. Shklyarevskiy, J.C.M. Hest, van

Research output: Contribution to journal › Article › Academic › peer-review

163 Citations (Scopus)

Abstract

The synthesis of two monomers based on glutamic acid and the peptide VPGVG (V = valine, P = proline, and G = glycine), a commonly found sequence in tropoelastin, was investigated. The polymerizations of both monomers using atom transfer radical polymerization (ATRP) proceeded in a controlled manner and yielded polymers with narrow molecular weight distributions. The VPGVG sequence in the side chain of the polymer still maintained its characteristic LOST (lower critical solution temperature) behavior, according to CD spectroscopy. Triblock copolymers were prepared by polymerizing, using ATRP, the VPGVG monomer with a bifunctional poly(ethylene glycol) (PEG)-based initiator. This resulted in a material that upon heating in water clearly formed aggregates. These reversible aggregates were investigated using turbidity measurements and dynamic light scattering. A pH-dependent transition temperature of 40-70 °C was observed.

Original language	English
Pages (from-to)	5967-5973
Number of pages	7
Journal	Macromolecules
Volume	36
Issue number	16
DOIs	https://doi.org/10.1021/ma025727h
Publication status	Published - 12 Aug 2003
Externally published	Yes

Access to Document

10.1021/ma025727h

Cite this

@article{f6b7922c8e38467db3c2a5d380e8ef85,

title = "Elastin-based side-chain polymers synthesized by ATRP",

abstract = "The synthesis of two monomers based on glutamic acid and the peptide VPGVG (V = valine, P = proline, and G = glycine), a commonly found sequence in tropoelastin, was investigated. The polymerizations of both monomers using atom transfer radical polymerization (ATRP) proceeded in a controlled manner and yielded polymers with narrow molecular weight distributions. The VPGVG sequence in the side chain of the polymer still maintained its characteristic LOST (lower critical solution temperature) behavior, according to CD spectroscopy. Triblock copolymers were prepared by polymerizing, using ATRP, the VPGVG monomer with a bifunctional poly(ethylene glycol) (PEG)-based initiator. This resulted in a material that upon heating in water clearly formed aggregates. These reversible aggregates were investigated using turbidity measurements and dynamic light scattering. A pH-dependent transition temperature of 40-70 °C was observed.",

author = "L. Ayres and M.R.J. Vos and P.J.H.M. Adams and I.O. Shklyarevskiy and {Hest, van}, J.C.M.",

year = "2003",

month = aug,

day = "12",

doi = "10.1021/ma025727h",

language = "English",

volume = "36",

pages = "5967--5973",

journal = "Macromolecules",

issn = "0024-9297",

publisher = "American Chemical Society",

number = "16",

}

TY - JOUR

T1 - Elastin-based side-chain polymers synthesized by ATRP

AU - Ayres, L.

AU - Vos, M.R.J.

AU - Adams, P.J.H.M.

AU - Shklyarevskiy, I.O.

AU - Hest, van, J.C.M.

PY - 2003/8/12

Y1 - 2003/8/12

N2 - The synthesis of two monomers based on glutamic acid and the peptide VPGVG (V = valine, P = proline, and G = glycine), a commonly found sequence in tropoelastin, was investigated. The polymerizations of both monomers using atom transfer radical polymerization (ATRP) proceeded in a controlled manner and yielded polymers with narrow molecular weight distributions. The VPGVG sequence in the side chain of the polymer still maintained its characteristic LOST (lower critical solution temperature) behavior, according to CD spectroscopy. Triblock copolymers were prepared by polymerizing, using ATRP, the VPGVG monomer with a bifunctional poly(ethylene glycol) (PEG)-based initiator. This resulted in a material that upon heating in water clearly formed aggregates. These reversible aggregates were investigated using turbidity measurements and dynamic light scattering. A pH-dependent transition temperature of 40-70 °C was observed.

AB - The synthesis of two monomers based on glutamic acid and the peptide VPGVG (V = valine, P = proline, and G = glycine), a commonly found sequence in tropoelastin, was investigated. The polymerizations of both monomers using atom transfer radical polymerization (ATRP) proceeded in a controlled manner and yielded polymers with narrow molecular weight distributions. The VPGVG sequence in the side chain of the polymer still maintained its characteristic LOST (lower critical solution temperature) behavior, according to CD spectroscopy. Triblock copolymers were prepared by polymerizing, using ATRP, the VPGVG monomer with a bifunctional poly(ethylene glycol) (PEG)-based initiator. This resulted in a material that upon heating in water clearly formed aggregates. These reversible aggregates were investigated using turbidity measurements and dynamic light scattering. A pH-dependent transition temperature of 40-70 °C was observed.

UR - http://www.scopus.com/inward/record.url?scp=0042475697&partnerID=8YFLogxK

U2 - 10.1021/ma025727h

DO - 10.1021/ma025727h

M3 - Article

AN - SCOPUS:0042475697

SN - 0024-9297

VL - 36

SP - 5967

EP - 5973

JO - Macromolecules

JF - Macromolecules

IS - 16

ER -

Elastin-based side-chain polymers synthesized by ATRP

Abstract

Access to Document

Other files and links

Fingerprint

Cite this