Elastin-based side-chain polymers synthesized by ATRP

L. Ayres, M.R.J. Vos, P.J.H.M. Adams, I.O. Shklyarevskiy, J.C.M. Hest, van

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Abstract

The synthesis of two monomers based on glutamic acid and the peptide VPGVG (V = valine, P = proline, and G = glycine), a commonly found sequence in tropoelastin, was investigated. The polymerizations of both monomers using atom transfer radical polymerization (ATRP) proceeded in a controlled manner and yielded polymers with narrow molecular weight distributions. The VPGVG sequence in the side chain of the polymer still maintained its characteristic LOST (lower critical solution temperature) behavior, according to CD spectroscopy. Triblock copolymers were prepared by polymerizing, using ATRP, the VPGVG monomer with a bifunctional poly(ethylene glycol) (PEG)-based initiator. This resulted in a material that upon heating in water clearly formed aggregates. These reversible aggregates were investigated using turbidity measurements and dynamic light scattering. A pH-dependent transition temperature of 40-70 °C was observed.

Original languageEnglish
Pages (from-to)5967-5973
Number of pages7
JournalMacromolecules
Volume36
Issue number16
DOIs
Publication statusPublished - 12 Aug 2003
Externally publishedYes

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    Ayres, L., Vos, M. R. J., Adams, P. J. H. M., Shklyarevskiy, I. O., & Hest, van, J. C. M. (2003). Elastin-based side-chain polymers synthesized by ATRP. Macromolecules, 36(16), 5967-5973. https://doi.org/10.1021/ma025727h