Elastin as a biomaterial for tissue engineering

W.F. Daamen, J.H. Veerkamp, J.C.M. van Hest, T.H. van Kuppevelt

Research output: Contribution to journalReview articlepeer-review

337 Citations (Scopus)

Abstract

Biomaterials based upon elastin and elastin-derived molecules are increasingly investigated for their application in tissue engineering. This interest is fuelled by the remarkable properties of this structural protein, such as elasticity, self-assembly, long-term stability, and biological activity. Elastin can be applied in biomaterials in various forms, including insoluble elastin fibres, hydrolysed soluble elastin, recombinant tropoelastin (fragments), repeats of synthetic peptide sequences and as block copolymers of elastin, possibly in combination with other (bio)polymers. In this review, the properties of various elastin-based materials will be discussed, and their current and future applications evaluated.

Original languageEnglish
Pages (from-to)4378-4398
Number of pages21
JournalBiomaterials
Volume28
Issue number30
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

Keywords

  • Biomaterial
  • Elastic fibre
  • Elastin
  • Review

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