TY - JOUR
T1 - Efficient computational simulation of actin stress fiber remodeling
AU - Ristori, T.
AU - Obbink-Huizer, C.
AU - Oomens, C.W.J.
AU - Baaijens, F.P.T.
AU - Loerakker, S.
PY - 2016/1/28
Y1 - 2016/1/28
N2 - Understanding collagen and stress fiber remodeling is essential for the development of engineered tissues with good functionality. These processes are complex, highly interrelated, and occur over different time scales. As a result, excessive computational costs are required to computationally predict the final organization of these fibers in response to dynamic mechanical conditions. In this study, an analytical approximation of a stress fiber remodeling evolution law was derived. A comparison of the developed technique with the direct numerical integration of the evolution law showed relatively small differences in results, and the proposed method is one to two orders of magnitude faster.
AB - Understanding collagen and stress fiber remodeling is essential for the development of engineered tissues with good functionality. These processes are complex, highly interrelated, and occur over different time scales. As a result, excessive computational costs are required to computationally predict the final organization of these fibers in response to dynamic mechanical conditions. In this study, an analytical approximation of a stress fiber remodeling evolution law was derived. A comparison of the developed technique with the direct numerical integration of the evolution law showed relatively small differences in results, and the proposed method is one to two orders of magnitude faster.
KW - Actin stress fiber remodeling
KW - analytical approximation
KW - cyclic strain
KW - ODE system with periodic coefficients
UR - http://www.scopus.com/inward/record.url?scp=84958056469&partnerID=8YFLogxK
U2 - 10.1080/10255842.2016.1140748
DO - 10.1080/10255842.2016.1140748
M3 - Article
C2 - 26823159
AN - SCOPUS:84958056469
SN - 1025-5842
VL - 19
SP - 1347
EP - 1358
JO - Computer Methods in Biomechanics and Biomedical Engineering
JF - Computer Methods in Biomechanics and Biomedical Engineering
IS - 12
ER -