Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.

LanguageEnglish
Title of host publicationMeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Number of pages6
ISBN (Electronic)978-1-5386-3392-2
ISBN (Print)978-1-5386-3393-9
DOIs
StatePublished - 16 Aug 2018
Event13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018 - Rome, Italy
Duration: 11 Jun 201813 Jun 2018

Conference

Conference13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018
CountryItaly
CityRome
Period11/06/1813/06/18

Fingerprint

Cardiac resynchronization therapy
Cardiac Resynchronization Therapy
Heart Ventricles
therapy
blood flow
Ultrasonics
Pressure
transponders
Blood
Speckle
Vorticity
Flow patterns
vorticity
flow distribution
Ventricular Dysfunction
Blood Flow Velocity
Aortic Valve
ejection
Flow velocity
Dilution

Keywords

  • contrast ultrasound
  • Left ventricle
  • velocity vector fields
  • ventricular pressure
  • vorticity

Cite this

Chen, P., van Sloun, R. J. G., Turco, S., Wijkstra, H., Houthuizen, P., & Mischi, M. (2018). Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. In MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings [8438752] Piscataway: Institute of Electrical and Electronics Engineers. DOI: 10.1109/MeMeA.2018.8438752
Chen, Peiran ; van Sloun, Ruud J.G. ; Turco, Simona ; Wijkstra, Hessel ; Houthuizen, Patrick ; Mischi, Massimo. / Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings. Piscataway : Institute of Electrical and Electronics Engineers, 2018.
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abstract = "Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.",
keywords = "contrast ultrasound, Left ventricle, velocity vector fields, ventricular pressure, vorticity",
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Chen, P, van Sloun, RJG, Turco, S, Wijkstra, H, Houthuizen, P & Mischi, M 2018, Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. in MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings., 8438752, Institute of Electrical and Electronics Engineers, Piscataway, 13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018, Rome, Italy, 11/06/18. DOI: 10.1109/MeMeA.2018.8438752

Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. / Chen, Peiran; van Sloun, Ruud J.G.; Turco, Simona; Wijkstra, Hessel; Houthuizen, Patrick; Mischi, Massimo.

MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings. Piscataway : Institute of Electrical and Electronics Engineers, 2018. 8438752.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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AB - Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.

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KW - velocity vector fields

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KW - vorticity

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SN - 978-1-5386-3393-9

BT - MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings

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Chen P, van Sloun RJG, Turco S, Wijkstra H, Houthuizen P, Mischi M. Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. In MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings. Piscataway: Institute of Electrical and Electronics Engineers. 2018. 8438752. Available from, DOI: 10.1109/MeMeA.2018.8438752