Abstract
Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.
| Original language | English |
|---|---|
| Title of host publication | MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings |
| Place of Publication | Piscataway |
| Publisher | Institute of Electrical and Electronics Engineers |
| Number of pages | 6 |
| ISBN (Electronic) | 978-1-5386-3392-2 |
| ISBN (Print) | 978-1-5386-3393-9 |
| DOIs | |
| Publication status | Published - 16 Aug 2018 |
| Event | 13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018 - Rome, Italy Duration: 11 Jun 2018 → 13 Jun 2018 |
Conference
| Conference | 13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018 |
|---|---|
| Country | Italy |
| City | Rome |
| Period | 11/06/18 → 13/06/18 |
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Keywords
- contrast ultrasound
- Left ventricle
- velocity vector fields
- ventricular pressure
- vorticity
Cite this
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Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. / Chen, Peiran; van Sloun, Ruud J.G.; Turco, Simona; Wijkstra, Hessel; Houthuizen, Patrick; Mischi, Massimo.
MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings. Piscataway : Institute of Electrical and Electronics Engineers, 2018. 8438752.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review
TY - GEN
T1 - Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates
AU - Chen, Peiran
AU - van Sloun, Ruud J.G.
AU - Turco, Simona
AU - Wijkstra, Hessel
AU - Houthuizen, Patrick
AU - Mischi, Massimo
PY - 2018/8/16
Y1 - 2018/8/16
N2 - Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.
AB - Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.
KW - contrast ultrasound
KW - Left ventricle
KW - velocity vector fields
KW - ventricular pressure
KW - vorticity
UR - http://www.scopus.com/inward/record.url?scp=85053118808&partnerID=8YFLogxK
U2 - 10.1109/MeMeA.2018.8438752
DO - 10.1109/MeMeA.2018.8438752
M3 - Conference contribution
AN - SCOPUS:85053118808
SN - 978-1-5386-3393-9
BT - MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings
PB - Institute of Electrical and Electronics Engineers
CY - Piscataway
ER -