Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Eva Magdalena Estirado, Bas J H M Rosier, Tom F A de Greef, Luc Brunsveld (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer.

Original languageEnglish
Pages (from-to)5747-5750
Number of pages4
JournalChemical Communications
Volume56
Issue number43
Early online date22 Apr 2020
DOIs
Publication statusPublished - 28 May 2020

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