Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Eva Magdalena Estirado, Bas J H M Rosier, Tom F A de Greef, Luc Brunsveld (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer.

Original languageEnglish
Pages (from-to)5747-5750
Number of pages4
JournalChemical Communications, ChemComm
Volume56
Issue number43
Early online date22 Apr 2020
DOIs
Publication statusPublished - 28 May 2020

Funding

This work was supported by The Netherlands Organization for Scientific Research (NWO) through Gravity Program 024.001.035, and through the European Union’s program Horizon 2020 Marie Curie Innovative Training Network MULTI APP (2015-2019).

FundersFunder number
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Horizon 2020 Framework Programme677313
Nederlandse Organisatie voor Wetenschappelijk Onderzoek024.001.035
Horizon 20202015-2019

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