This paper deals with low frequency pulsation phenomena in full-scale centrifugal compression systems associated with compressor surge. The Greitzer lumped parameter model is applied to describe the dynamic behavior of an industrial compressor test rig and experimental evidence is provided for the presence of acoustic pulsations in the compression system under study. It is argued that these acoustic phenomena are common for full-scale compression systems where pipe system dynamics have a significant influence on the overall system behavior.The main objective of this paper is to extend the basic compressor model in order to include the relevant pipe system dynamics. For this purpose a pipeline model is proposed, based on previous developments for fluid transmission lines. The connection of this model to the lumped parameter model is accomplished via the selection of appropriate boundary conditions.Validation results will be presented, showing a good agreement between simulation and measurement data.The results indicate that the damping of piping transients depends on the nominal, time-varying pressure and flow velocity. Therefore, model parameters are made dependent on the momentary pressure and a switching nonlinearity is introduced into the model to vary the acoustic damping as a function of flow velocity.These modifications have limited success and the results indicate that a more sophisticated model is required to fully describe all (nonlinear) acoustic effects. However, the very good qualitative results show that the model adequately combines compressor and pipe system dynamics. Therefore, the proposed model forms a step forward in the analysis and modeling of surge in full-scale centrifugal compression systems and opens the path for further developments in this field.