TY - JOUR
T1 - Dynamic contrast-enhanced magnetic resonance imaging at 1.5 Tesla with gadopentetate dimeglumine to assess the angiostatic effects of anginex in mice.
AU - Lussanet, de, Q.G.
AU - Beets-Tan, R.G.H.
AU - Backes, W.H.
AU - Schaft, van der, D.W.J.
AU - Engelshoven, van, J.M.A.
AU - Mayo, K.H.
AU - Griffioen, A.W.
PY - 2004
Y1 - 2004
N2 - The purpose of this study was to evaluate the effects of anginex on tumour angiogenesis assessed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on a clinical 1.5 Tesla MR system and with the clinically available contrast agent gadopentetate dimeglumine. C57BL/6 mice carrying B16F10 melanomas were treated with anginex, TNP-470 or saline. Tumour growth curves and microvessel density (MVD) were recorded to establish the effects of treatment. DCE-MRI was performed on day 16 after tumour inoculation, and the endothelial transfer coefficients of the microvessel permeability surface-area product (KPS) were calculated using a two-compartment model. Both anginex and TNP-470 resulted in smaller tumour volumes (P
AB - The purpose of this study was to evaluate the effects of anginex on tumour angiogenesis assessed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on a clinical 1.5 Tesla MR system and with the clinically available contrast agent gadopentetate dimeglumine. C57BL/6 mice carrying B16F10 melanomas were treated with anginex, TNP-470 or saline. Tumour growth curves and microvessel density (MVD) were recorded to establish the effects of treatment. DCE-MRI was performed on day 16 after tumour inoculation, and the endothelial transfer coefficients of the microvessel permeability surface-area product (KPS) were calculated using a two-compartment model. Both anginex and TNP-470 resulted in smaller tumour volumes (P
U2 - 10.1016/j.ejca.2004.01.020
DO - 10.1016/j.ejca.2004.01.020
M3 - Article
C2 - 15110892
SN - 0959-8049
VL - 40
SP - 1262
EP - 1268
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 8
ER -