Duality of glucocorticoid action in cancer: Tumor-suppressor or oncogene?

Isabel Mayayo-Peralta, Wilbert Zwart (Corresponding author), Stefan Prekovic (Corresponding author)

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Glucocorticoid receptor (GR) is a key homeostatic regulator involved in governing immune response, neuro-integration, metabolism and lung function. In conjunction with its pivotal role in human biology, GR action is critically linked to the pa thology of various disease types, including cancer. While pharmacological activation of GR has been used for the treatment of various liquid cancers, its role in solid cancers is less clearly defined and seems to be cancer-type dependent. This review focuses on the m olecular aspects of GR biology, spanning the structural and functional basis of response to glucocorticoids, as well as how this transcription factor operates in cancer, in cluding the implications in disease development, progression and drug resistance.

Original languageEnglish
Pages (from-to)R157-R171
JournalEndocrine-related cancer
Volume28
Issue number6
DOIs
Publication statusPublished - 11 May 2021

Bibliographical note

Funding Information:
This work was supported by the Netherlands Organization for Scientific Research NWO V 阀D 阀 (91716401); an Alpe d’Huzes/KWF Bas Mulder Award; KWF (12128); and Oncode 阀nstitute.

Publisher Copyright:
© 2021 Society for Endocrinology.

Funding

This work was supported by the Netherlands Organization for Scientific Research NWO V 阀D 阀 (91716401); an Alpe d’Huzes/KWF Bas Mulder Award; KWF (12128); and Oncode 阀nstitute.

Keywords

  • Cancer
  • Glucocorticoid receptor
  • Glucocorticoids
  • Nuclear receptor
  • Transcriptional regulation

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