Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle

Kemal Sumser; Gennaro G. Bellizzi; Ria Forner; Tomas Drizdal; Juan A. Hernandez Tamames; Gerard C. van Rhoon; Margarethus M. Paulides

doi:10.1109/tbme.2020.3012734

Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle

Kemal Sumser (Corresponding author), Gennaro G. Bellizzi, Ria Forner, Tomas Drizdal, Juan A. Hernandez Tamames, Gerard C. van Rhoon, Margarethus M. Paulides

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Abstract

Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal due to technological and intrinsic limitations. These hamper achieving target conformal heating possibilities (applicator limitations) and accurate thermometry (inadequate signal-to-noise-ratio (SNR)). In this work, we studied proof of principle of a dual-function hyperthermia approach based on a coil array (64 MHz, 1.5 T) that is integrated in-between a phased array for heating (434 MHz) for maximum signal receive in order to improve thermometry accuracy. Hereto, we designed and fabricated a superficial hyperthermia mimicking planar array setup to study the most challenging interactions of generic phased-array setups in order to validate the integrated approach. Experiments demonstrated that the setup complies with the superficial hyperthermia guidelines for heating and is able to improve SNR at 2-4 cm depth by 17%, as compared to imaging using the body coil. Hence, the results showed the feasibility of our dual-function MR-guided hyperthermia approach as basis for the development of application specific setups.

Original language	English
Article number	9152076
Pages (from-to)	712-717
Number of pages	6
Journal	IEEE Transactions on Biomedical Engineering
Volume	68
Issue number	2
Early online date	29 Jul 2020
DOIs	https://doi.org/10.1109/tbme.2020.3012734
Publication status	Published - Feb 2021

Funding

Manuscript received in Jan. 2020. * These authors contributed equally to this work. This work was supported by the project KWF-11368 - “Multi-coil magnetic resonance guided hyperthermia for precision treatment of advanced head and neck carcinoma” and supported by COST Action MyWave CA17115 -“European network for advancing Electromagnetic hyperthermic medical technologies”. K. Sumser, G.G. Bellizzi, G.C. va Rhoon and M.M. Paulides is with Department of Radiation Oncology, University Medical Center Rotterdam, Erasmus MC – Cancer Institute, Rotterdam, The Netherlands ([email protected]) R. Forner is with Department of Radiology, Utrecht Medical Center, Utrecht, The Netherlands T. Drizdal is with Department of Biomedical Technology, Czech Technical University in Prague, Prague, Czech Republic J.A. Hernandez Tamames is with Department of Radiology & Nuclear Medicine, University Medical Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands G.C. van Rhoon is also with Department of Applied Radiation and Isotopes, Reactor Institute Delft, Delft, The Netherlands M.M. Paulides is also with Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

Keywords

Hyperthermia
MR thermometry
MR-guided treatment
Phased array integration
Radiofrequency

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abstract = "Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal due to technological and intrinsic limitations. These hamper achieving target conformal heating possibilities (applicator limitations) and accurate thermometry (inadequate signal-to-noise-ratio (SNR)). In this work, we studied proof of principle of a dual-function hyperthermia approach based on a coil array (64 MHz, 1.5 T) that is integrated in-between a phased array for heating (434 MHz) for maximum signal receive in order to improve thermometry accuracy. Hereto, we designed and fabricated a superficial hyperthermia mimicking planar array setup to study the most challenging interactions of generic phased-array setups in order to validate the integrated approach. Experiments demonstrated that the setup complies with the superficial hyperthermia guidelines for heating and is able to improve SNR at 2-4 cm depth by 17%, as compared to imaging using the body coil. Hence, the results showed the feasibility of our dual-function MR-guided hyperthermia approach as basis for the development of application specific setups.",

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Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle. / Sumser, Kemal (Corresponding author); Bellizzi, Gennaro G.; Forner, Ria et al.
In: IEEE Transactions on Biomedical Engineering, Vol. 68, No. 2, 9152076, 02.2021, p. 712-717.

Research output: Contribution to journal › Article › Academic › peer-review

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Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle

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