Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle

Kemal Sumser (Corresponding author), Gennaro G. Bellizzi, Ria Forner, Tomas Drizdal, Juan A. Hernandez Tamames, Gerard C. van Rhoon, Margarethus M. Paulides

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
208 Downloads (Pure)


Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal due to technological and intrinsic limitations. These hamper achieving target conformal heating possibilities (applicator limitations) and accurate thermometry (inadequate signal-to-noise-ratio (SNR)). In this work, we studied proof of principle of a dual-function hyperthermia approach based on a coil array (64 MHz, 1.5 T) that is integrated in-between a phased array for heating (434 MHz) for maximum signal receive in order to improve thermometry accuracy. Hereto, we designed and fabricated a superficial hyperthermia mimicking planar array setup to study the most challenging interactions of generic phased-array setups in order to validate the integrated approach. Experiments demonstrated that the setup complies with the superficial hyperthermia guidelines for heating and is able to improve SNR at 2-4 cm depth by 17%, as compared to imaging using the body coil. Hence, the results showed the feasibility of our dual-function MR-guided hyperthermia approach as basis for the development of application specific setups.

Original languageEnglish
Article number9152076
Pages (from-to)712-717
Number of pages6
JournalIEEE Transactions on Biomedical Engineering
Issue number2
Early online date29 Jul 2020
Publication statusPublished - Feb 2021


  • Hyperthermia
  • MR thermometry
  • MR-guided treatment
  • Phased array integration
  • Radiofrequency


Dive into the research topics of 'Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle'. Together they form a unique fingerprint.

Cite this