TY - JOUR
T1 - Dual-emissive quantum dots for multispectral intraoperative fluorescence imaging
AU - Chin, P.T.K.
AU - Buckle, T.
AU - Aguirre de Miguel, A.
AU - Meskers, S.C.J.
AU - Janssen, R.A.J.
AU - Leeuwen, van, F.W.B.
PY - 2010
Y1 - 2010
N2 - Fluorescence molecular imaging is rapidly increasing its popularity in image guided surgery applications. To help develop its full surgical potential it remains a challenge to generate dual-emissive imaging agents that allow for combined visible assessment and sensitive camera based imaging. To this end, we now describe multispectral InP/ZnS quantum dots (QDs) that exhibit a bright visible green/yellow exciton emission combined with a long-lived far red defect emission. The intensity of the latter emission was enhanced by X-ray irradiation and allows for: 1) inverted QD density dependent defect emission intensity, showing improved efficacies at lower QD densities, and 2) detection without direct illumination and interference from autofluorescence.
AB - Fluorescence molecular imaging is rapidly increasing its popularity in image guided surgery applications. To help develop its full surgical potential it remains a challenge to generate dual-emissive imaging agents that allow for combined visible assessment and sensitive camera based imaging. To this end, we now describe multispectral InP/ZnS quantum dots (QDs) that exhibit a bright visible green/yellow exciton emission combined with a long-lived far red defect emission. The intensity of the latter emission was enhanced by X-ray irradiation and allows for: 1) inverted QD density dependent defect emission intensity, showing improved efficacies at lower QD densities, and 2) detection without direct illumination and interference from autofluorescence.
U2 - 10.1016/j.biomaterials.2010.05.030
DO - 10.1016/j.biomaterials.2010.05.030
M3 - Article
C2 - 20619786
VL - 31
SP - 6823
EP - 6832
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 26
ER -