Abstract
Dual electrospinning can be used to make multifunctional scaffolds for regenerative medicine applications. Here, two supramolecular polymers with different material properties are electrospun simultaneously to create a multifibrous mesh. Bisurea (BU)-based polycaprolactone, an elastomer providing strength to the mesh, and ureido-pyrimidinone (UPy) modified poly(ethylene glycol) (PEG), a hydrogelator, introducing the capacity to deliver compounds upon swelling. The dual spun scaffolds are modularly tuned by mixing UPyPEG hydrogelators with different polymer lengths, to control swelling of the hydrogel fiber, while maintaining the mechanical properties of the scaffold. Stromal cell derived factor 1 alpha (SDF1α) peptides are embedded in the UPyPEG fibers. The swelling and erosion of UPyPEG increase void spaces and released the SDF1α peptide. The functionalized scaffolds demonstrate preferential lymphocyte recruitment proposed to be created by a gradient formed by the released SDF1α peptide. This delivery approach offers the potential to develop multifibrous scaffolds with various functions.
Original language | English |
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Article number | 1800004 |
Number of pages | 9 |
Journal | Macromolecular Bioscience |
Volume | 18 |
Issue number | 7 |
Early online date | 5 Jun 2018 |
DOIs | |
Publication status | Published - 1 Jul 2018 |
Funding
The author would like to thank SyMO-Chem for providing the supramolecular materials. The authors would like to thank C. Mondadori and L. Sacco for their technical assistance and M. Putti for useful discussions. This research was supported by a grant from the Dutch government to the Netherlands Institute for Regenerative Medicine (NIRM) and their contribution is gratefully acknowledged. Additionally, this work was supported by the Ministry of Education, Culture and Science (Gravity program 024.001.035), and the European Research Council (FP7/2007-2013) under ERC Grant Agreement No. 308045.
Keywords
- cell recruitment
- electrospinning
- multicomponent material
- SDF1alpha
- supramolecular polymers